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- FAN1 rabbit pAb
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FAN1 rabbit pAb
- Catalog No.:YT7724
- Applications:WB
- Reactivity:Human;Mouse
- Fields:
- >>Fanconi anemia pathway
- Gene Name:
- FAN1 KIAA1018 MTMR15
- Immunogen:
- Synthesized peptide derived from human FAN1 AA range: 801-851
- Specificity:
- This antibody detects endogenous levels of FAN1 at Human/Mouse
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 112kD
- Background:
- This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016],
- Function:
- similarity:Belongs to the MTMR15 family.,
- Subcellular Location:
- Nucleus . Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2 (PubMed:20603015, PubMed:20603016). Localizes to stalled replication forks via its UBZ4-type zinc finger (PubMed:20935496). .
- Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night