• Target：
• Rabbit IgG(H+L)

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Goat

• Dilution：
• WB 1:5000-20000;IHC 1:20-100;ELISA 1:5000-20000

• Purification：
• The antibody was affinity-purified from goat antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 4 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• HRP* Goat Anti-Rabbit IgG(H+L)

• Background：
• Immunoway secondary antibodies are available conjugated to enzyme, biotin or fluorophore for use in a variety of antibody-based applications including Western Blot, ImmunoHistoChemistry, ImmunoFluorescence, Flow Cytometry and ELISA. We offer high quality secondary antibodies from goat, rabbit and donkey sources for your each application. Serum adsorbed secondary antibodies are also available and are recommended for use with immunoglobulin-rich samples.

CXCR1 and its downstream NF-κB inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injury.

Anti-hyperuricemic, Nephroprotective and Gut Microbiota Regulative Effects of Separated Hydrolysate of α-lactalbumin on Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice

Melatonin alleviates lead-induced intestinal epithelial cell pyroptosis in the common carps (Cyprinus carpio) via miR-17-5p/TXNIP axis

Melatonin alleviates lead-induced intestinal epithelial cell pyroptosis in the common carps (Cyprinus carpio) via miR-17-5p/TXNIP axis

Hsa_circ_0001550 impairs decidualization by regulating the proliferation and apoptosis of endometrial stromal cells

Selenium Mitigates Ammonia-Induced Neurotoxicity by Suppressing Apoptosis, Immune Imbalance, and Gut Microbiota-Driven Metabolic Disturbance in Fattening Pigs.

Neuroprotection of boropinol-B in Cerebral Ischemia-reperfusion Injury by Inhibiting Inflammation and Apoptosis

Melatonin alleviates lead-induced fatty liver in the common carps (Cyprinus carpio) via gut-liver axis

Ganoderma lucidum polysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters

FOXG1 Contributes Adult Hippocampal Neurogenesis in Mice

MED1 Ablation Promotes Oral Mucosal Wound Healing via JNK Signaling Pathway

Entrectinib ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β1 signaling pathway

Tacrolimus ameliorates bleomycin-induced pulmonary fibrosis by inhibiting M2 macrophage polarization via JAK2/STAT3 signaling

Tannic acid antagonizes atrazine exposure-induced autophagy and DNA damage crosstalk in grass carp hepatocytes via NO/iNOS/NF-κB signaling pathway to maintain stable immune function

Combined negative effects of microplastics and plasticizer DEHP: The increased release of Nets delays wound healing in mice SCIENCE OF THE TOTAL ENVIRONMENT Xu Shi, Tong Xu, Wei Cui, Xue Qi, Shiwen Xu WB Mouse skin tissue neutrophils,fibroblasts

Astragaloside IV alleviates cytarabine-induced intestinal mucositis by remodeling macrophage polarization through AKT signaling PHYTOMEDICINE Jun-jie LI, Ya-ling LI, Wei CHU, Gao-qin LI, Min ZHANG, Juan-juan DONG, Ling LI, Cheng-hao LI, Jin-bao ZHANG, Jia-wei LI, Xiao-jie JIN, Yong-qi LIU WB Mouse intestinal RAW264.7 cell

Halofuginone ameliorates systemic lupus erythematosus by targeting Blk in myeloid-derived suppressor cells INTERNATIONAL IMMUNOPHARMACOLOGY Jiali Ni, Xiaoying Li, Xiaodi Tu, Haiyan Zhu, Shiqi Wang, Yayi Hou, Huan Dou WB Mouse MDSCs

Selenium mitigates the inhibitory effect of TBBPA on NETs release by regulating ROS/MAPK pathways-induced carp neutrophil apoptosis and necroptosis FISH & SHELLFISH IMMUNOLOGY Duqiang Gong, Kexin Sun, Kexin Yin, Xu Wang WB Fish neutrophil

Novel immunogenic cell death-related risk signature to predict prognosis and immune microenvironment in lung adenocarcinoma JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY Li, Qixuan, Tang, Yijie, Wang, Tianyi, Zhu, Jiaqi, Zhou, Youlang, Shi, Jiahai WB Human BEAS-2B cell, PC9 cell, H1650 cell, H23 cell, A549 cell

Astaxanthin Prevents Tuberculosis-Associated Inflammatory Injury by Inhibiting the Caspase 4/11-Gasdermin-Pyroptosis Pathway Evidence-based Complementary and Alternative Medicine Li Li, Zulipikaer Abudureheman, Xuemei Zhong, Liang Gao, Hui Gong, Chuanjiang He, Boyi Yang, Jie Ren, Ayiguli Alimu, Subinuer Yilamujiang, Fan Yang, Xiaoguang Zou WB Mouse MLE-12 cell

Protective effect of Cistanche deserticola on gentamicin-induced nephrotoxicity in rats Chinese Herbal Medicines Rui-bin Bai, Jing-min Fan, Yan-ping Wang, Yan Wang, Xue Li, Fang-di Hu WB Rat kidney

STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway WB Mouse lung tissues/human bronchial epithelial HBE cells

Assessment of Fasudil on Contrast-Associated Acute Kidney Injury Using Multiparametric Renal MRI WB Rat 1:10000 kidney tissues/

The endoplasmic reticulum-mitochondrial crosstalk is involved in the mitigation mechanism of eucalyptol on imidacloprid toxicity in Ctenopharyngodon idellus kidney cells WB Fish 1:10000 /Ctenopharyngodon idellus kidney (CIK) cells

A radiation resistance related index for biochemical recurrence and tumor immune environment in prostate cancer patients WB Human 1:10000 /PC-3, DU145 cells

Effect of eplerenone on cognitive impairment in spontaneously hypertensive rats WB Rat 1:5000 hippocampal tissue/

Shen Qi Wan Ameliorates Learning and Memory Impairment Induced by STZ in AD Rats through PI3K/AKT Pathway WB Mouse 1:5000 hippocampus tissue/

Parkin, as a Regulator, Participates in Arsenic Trioxide-Triggered Mitophagy in HeLa Cells WB Human 1:5000 /HeLa cells

Dietary Fatty Acid Regulation of the NLRP3 Inflammasome via the TLR4/NF-κB Signaling Pathway Affects Chondrocyte Pyroptosis WB Mouse 1 : 5000 articular cartilage/

Bisphenol a exposure decreases learning ability through the suppression of mitochondrial oxidative phosphorylation in the hippocampus of male mice WB Mouse 1:10000 hippocampus /

Proteomic Study on the Reproductive Toxicity of Tripterygium Glycosides in Rats WB Rat testis tissue /

Design, Synthesis, and Apoptosis-Promoting Effect Evaluation of Rhopaladins’ Analog 4-Arylidene-5-Oxopyrrolidine Derivatives WB Human 1:5000 /HepG2 cell, 7402 cell

Eucalyptol relieves imidacloprid-induced autophagy through the miR-451/Cab39/AMPK axis in Ctenopharyngodon idellus kidney cells† WB Fish 1:10000 /Ctenopharyngodon idellus kidney cell line (CIK cell)

Neuronal STAT3/HIF-1α/PTRF axis-mediated bioenergetic disturbance exacerbates cerebral ischemia-reperfusion injury via PLA2G4A. Theranostics2022; 12(7): 3196–3216. Mouse 1:10000 HT22 cell

Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway. Stem Cell Research & Therapy2022 Dec;13(1):1-15. Human,Mouse 1:3000 liver tissue hUC-MSC

The CK1δ/ϵ-Tip60 Axis Enhances Wnt/β-Catenin Signaling via Regulating β-Catenin Acetylation in Colon Cancer. Frontiers in Oncology2022 Apr;0:1567. Human HEK293T cell

Licoflavone A Suppresses Gastric Cancer Growth and Metastasis by Blocking the VEGFR-2 Signaling Pathway. Journal of Oncology2022;2022:5497991. Human 1 : 1000 MKN-45 cell

Ferroptosis contributes to methylmercury-induced cytotoxicity in rat primary astrocytes and Buffalo rat liver cells. NEUROTOXICOLOGY2022 May;90:228. Rat AST cell, BRL cell

mTORC1 is a key regulator that mediates OGD‑ and TGFβ1‑induced myofibroblast transformation and chondroitin‑4‑sulfate expression in cardiac fibroblasts. Experimental and Therapeutic Medicine2022 Jun;23(6):1-13. Rat cardiac fibroblasts (CFs)

LncRNA TUG1 Promotes Apoptosis, Invasion, and Angiogenesis of Retinal Endothelial Cells in Retinopathy of Prematurity via MiR-145-5p. Frontiers in Medicine2022 Apr 4;9:803214. Mouse 1:1000 retinal tissue

Cineole alleviates the BPA-inhibited NETs formation by regulating the p38 pathway-mediated programmed cell death. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY2022 Jun;237:113558. Chicken 1:8000 neutrophil extracellular traps (NETs)

Chronic exposure of bisphenol-A impairs cognitive function and disrupts hippocampal insulin signaling pathway in male mice. TOXICOLOGY2022 Apr;472:153192. Mouse 1:10000 hippocampal tissues

Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis. ARTHRITIS RESEARCH & THERAPY2022 Dec;24(1):1-14. Human cartilage tissue chondrocytes

Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms Free Radical Bio Med. 2022 Mar;182:59. WB Mouse 1:10000 cerebral cortical

STAT6/VDR Axis Mitigates Lung Inflammatory Injury by Promoting Nrf2 Signaling Pathway Oxid Med Cell Longev. 2022;2022:2485250. WB,IF,IHC Mouse,Human lung

Lysine decrotonylation of glutathione peroxidase at lysine 220 site increases glutathione peroxidase activity to resist cold stress in chrysanthemum Ecotox Environ Safe. 2022 Mar;232:113295. WB Chrysanthemum 1:10000 leaves

Eurotium cristatum, a Probiotic Fungus from Fuzhuan Brick Tea, and Its Polysaccharides Ameliorated DSS-Induced Ulcerative Colitis in Mice by Modulating the Gut Microbiota J Agr Food Chem. 2022;70(9):2957–2967. WB Mouse colon tissues

Daurisoline alleviated experimental colitis in vivo and in vitro: Involvement of NF-κB and Wnt/β-Catenin pathway Int Immunopharmacol. 2022 Jul;108:108714. WB Mouse colon

Exosomal miR-543 Inhibits the Proliferation of Ovarian Cancer by Targeting IGF2 J Immunol Res. 2022;2022:2003739. WB Human

The Long-Noncoding RNA TUG1 Regulates Oxygen-Induced Retinal Neovascularization in Mice via MiR-299 Invest Ophth Vis Sci. 2022 Jan;63(1):37-37. WB Mouse 1:2000 retina

Secretion of BMP-2 by tumor-associated macrophages (TAM) promotes microcalcifications in breast cancer Bmc Cancer. 2022 Dec;22(1):1-9. WB Human 1:1000

Positive effects of selenium supplementation on selenoprotein S expression and cytokine status in a murine model of acute liver injury J Trace Elem Med Bio. 2022 May;71:126927. WB Mouse liver

Taurine supplementation improves hippocampal metabolism in immature rats with intrauterine growth restriction (IUGR) through protecting neurons and reducing gliosis Metab Brain Dis. 2022 Jan;:1-12. WB Rat 1:5000 brain

Angiopoietin-like protein 4 promotes hyperlipidemia-induced renal injury by down-regulating the expression of ACTN4 Biochem Bioph Res Co. 2022 Mar;595:69. IHC Mouse Renal

Protective effects of endotoxin tolerance on peripheral lipopolysaccharide-induced neuroinflammation and dopaminergic neuronal injury 2022 Mar 09. WB Mouse 1:5000 midbrain

MiR-181a-5p alleviates the inflammatory response of PC12 cells by inhibiting high-mobility group box-1 protein expression World Neurosurg. 2022 Mar;:. WB Rat 1:10000

Ammonia Regulates Chicken Tracheal Cell Necroptosis via the LncRNA-107053293/MiR-148a-3p/FAF1 Axis. JOURNAL OF HAZARDOUS MATERIALS J Hazard Mater. 2020 Mar;386:121626 WB Chicken 1:8000 trachea tissues

The Hippo signaling component LATS2 enhances innate immunity to inhibit HIV-1 infection through PQBP1-cGAS pathway. CELL DEATH AND DIFFERENTIATION Cell Death Differ. 2021 Aug;:1-14 IF Human HeLa cell， THP1 cell

MiR-378a-3p as a putative biomarker for hepatocellular carcinoma diagnosis and prognosis: Computational screening with experimental validation. Clinical and Translational Medicine Clin Transl Med. 2021 Feb;11(2):e307 WB Human 1:12000 SMMC-7721 cell

RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH J Exp Clin Canc Res. 2021 Dec;40(1):1-18 WB Human 1:5000 AMC-HN-8 cell，LSCC cell，TU-212 cell

Hydrogen sulfide exposure induces pyroptosis in the trachea of broilers via the regulatory effect of circRNA-17828/miR-6631-5p/DUSP6 crosstalk on ROS production. JOURNAL OF HAZARDOUS MATERIALS J Hazard Mater. 2021 Sep;418:126172 WB Broiler 1:8000，1:10000 Trachea

Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells. Cell Death & Disease Cell Death Dis. 2021 May;12(5):1-13 IHC Human Skin

New insights into crosstalk between apoptosis and necroptosis co-induced by chlorothalonil and imidacloprid in Ctenopharyngodon idellus kidney cells. SCIENCE OF THE TOTAL ENVIRONMENT Sci Total Environ. 2021 Aug;780:146591 WB Ctenopharyngodon idellus (grass carp） 1:10000 CIK cell

Obacunone Retards Renal Cyst Development in Autosomal Dominant Polycystic Kidney Disease by Activating NRF2. Antioxidants Antioxidants-Basel. 2022 Jan;11(1):38 WB Mouse Kidney

Cadmium exposure activates the PI3K/AKT signaling pathway through miRNA-21, induces an increase in M1 polarization of macrophages, and leads to fibrosis of pig liver tissue. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Ecotox Environ Safe. 2021 Dec;228:113015 WB Pig 1:10000 Liver

Upregulation of autophagy in M2 macrophage by vitamin D alleviates crystalline silica-induced pulmonary inflammatory damage. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Ecotox Environ Safe. 2021 Dec;225:112730 IF Human THP-1 cell

Autophagy was activated against the damages of placentas caused by nano-copper oral exposure. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Ecotox Environ Safe. 2021 Sep;220:112364 WB Rat 1：1000000 Placentas

KDF1, a Novel Tumor Suppressor in Clear Cell Renal Cell Carcinoma. Frontiers in Oncology Front Oncol. 2021; 11: 686678 WB Human Non-tumor renal tissue,ccRCC tumor tissue

Developmental Exposure to Atrazine Impairs Spatial Memory and Downregulates the Hippocampal D1 Dopamine Receptor and cAMP-Dependent Signaling Pathway in Rats. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Int J Mol Sci. 2018 Aug;19(8):2241 WB Rat 1:5000 hippocampal tissue

Selenium deficiency induced necroptosis, Th1/Th2 imbalance, and inflammatory responses in swine ileum. JOURNAL OF CELLULAR PHYSIOLOGY J Cell Physiol. 2021 Jan;236(1):222-234 WB Pig 1:25000 Ileum tissue IPEC-J2 cell

Matrix Remodeling Associated 7 Deficiency Alleviates Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Frontiers in Immunology 2018 Apr 18 WB Mouse liver tissues

Sucralose enhances the susceptibility to dextran sulfate sodium (DSS) induced colitis in mice with changes in gut microbiota. Food & Function Food Funct. 2021 Oct;12(19):9380-9390 WB Mouse Colonic tissue

Sesamin protects against DSS-induced colitis in mice by inhibiting NF-κB and MAPK signaling pathways. Food & Function Food Funct. 2021 Mar;12(4):1688-1694 WB Mouse Colonic tissue

Isorhamnetin Promotes MKN-45 Gastric Cancer Cell Apoptosis by Inhibiting PI3K-Mediated Adaptive Autophagy in a Hypoxic Environment. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY J Agr Food Chem. 2021;XXXX(XXX):XXX-XXX WB Human MKN-45 cells

The osteogenic effects of porous Tantalum and Titanium alloy scaffolds with different unit cell structure. COLLOIDS AND SURFACES B-BIOINTERFACES Colloid Surface B. 2022 Feb;210:112229 WB Rat 1:5000 rat bone mesenchymal stem cells

Bixin Protects Against Kidney Interstitial Fibrosis Through Promoting STAT6 Degradation. Frontiers in Cell and Developmental Biology Front Cell Dev Biol. 2020; 8: 576988 IF Human HK2 cell

Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β. BIOCHEMICAL PHARMACOLOGY Biochem Pharmacol. 2020 Aug;178:114097 WB Mouse,Human lung HFL1 cell ， Mlg cell，A549 cell，MLE12 cell

Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis. STRUCTURE Structure. 2020 May;28:555 WB Human HEK293T Cell

C4BPA: A Novel Co-Regulator of Immunity and Fat Metabolism in the Bovine Mammary Epithelial Cells.. Frontiers in Genetics Front Genet. 2021 Jan;12:830566-830566 WB Bovine bMECs

Deglycosylated Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis via the TGF-β1 Signaling Pathway. MOLECULES Molecules. 2021 Jan;26(9):2820 WB Mouse Lung NIH-3T3 cell

Mechanism by which Huoxue Tongluo Qiwei Decoction improves the erectile function of rats with diabetic erectile dysfunction. JOURNAL OF ETHNOPHARMACOLOGY J Ethnopharmacol. 2022 Jan;283:114674 WB Rat Cavernosum tissue

Maspin enhances cisplatin chemosensitivity in bladder cancer T24 and 5637 cells and correlates with prognosis of muscle-invasive bladder cancer patients receiving cisplatin based neoadjuvant chemotherapy. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2016 Jan 06 WB Human 1:4000 T24 cell, 5637 cell

Subacute cadmium exposure promotes M1 macrophage polarization through oxidative stress-evoked inflammatory response and induces porcine adrenal fibrosis. TOXICOLOGY Toxicology. 2021 Sep;461:152899 WB Pig 1:20000 Adrenal gland

A novel halogenated adenosine analog 5’-BrDA displays potent toxicity against colon cancer cells in vivo and in vitro. TOXICOLOGY AND APPLIED PHARMACOLOGY Toxicol Appl Pharm. 2022 Feb;436:115857 WB Human 1 : 5000 HT-29 cell

Bixin Confers Prevention against Ureteral Obstruction-Caused Renal Interstitial Fibrosis through Activation of the Nuclear Factor Erythroid-2-Related Factor2 Pathway in Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY J Agr Food Chem. 2020;68(31):8321–8329 IF Human HK2 cell

Unique Tubulin-Based Structures in the Zoonotic Apicomplexan Parasite Cryptosporidium parvum. Microorganisms Microorganisms. 2021 Sep;9(9):1921 WB C. parvum 1:10000 Sporozoite crude extracts

By Increasing the Expression and Activation of STAT3, Sustained C5a Stimulation Increases the Proliferation, Migration, and Invasion of RCC Cells and Promotes the Growth of Transgrafted Tumors. Cancer Management and Research Cancer Manag Res. 2021 Oct;13:7607-7621 WB Human 1:10000 786-O cell，ACHN cells

LncRNA PVT1 regulates VEGFC through inhibiting miR‐128 in bladder cancer cells. JOURNAL OF CELLULAR PHYSIOLOGY 2018 Aug 04 WB Human 1:1000 UM-UC-3 cell

lncRNA LA16c‑313D11.11 modulates the development of endometrial cancer by binding to and inhibiting microRNA‑205‑5p function and indirectly increasing PTEN activity. INTERNATIONAL JOURNAL OF ONCOLOGY Int J Oncol. 2020 Jul;57(1):355-363 WB Human 1:5000 HEC-1A cell, Ishikawa cell

The Abilities of Salidroside on Ameliorating Inflammation, Skewing the Imbalanced Nucleotide Oligomerization Domain-Like Receptor Family Pyrin Domain Containing 3/Autophagy, and Maintaining Intestinal Barrier Are Profitable in Colitis. Frontiers in Pharmacology 2019 Dec 02 WB,IHC Mouse colon

Post-self-repair process of neuron cells under the influence of neutral and cationic nanoparticles. CHINESE CHEMICAL LETTERS 2019 Nov 15 WB Mouse RGC-5 cell

Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA‐30a in breast cancer. MOLECULAR CARCINOGENESIS Mol Carcinogen. 2020 Aug;59(8):908-922 WB Human MCF-7 cell,MDA-MB-231 cell

The effect of miR-223 on cellular behaviour in non-5q myelodysplastic syndromes through targeting RPS14. PATHOLOGY Pathology. 2020 Aug;52:552 WB Human SKM-1 cell

Dipotassium glycyrrhizinate relieves leptospira-induced nephritis in vitro and in vivo. MICROBIAL PATHOGENESIS Microb Pathogenesis. 2021 Mar;152:104770 WB Mouse 1 : 20000 TCMK-1 cell

Liraglutide protects pancreatic β cells from endoplasmic reticulum stress by upregulating MANF to promote autophagy turnover. LIFE SCIENCES Life Sci. 2020 Jul;252:117648 WB Rat MIN6 cell

Implication of Potential Differential Roles of the Two Phosphoglucomutase Isoforms in the Protozoan Parasite Cryptosporidium parvum. Pathogens Pathogens. 2022 Jan;11(1):21 WB Human 1:5000 HCT-8 cell

Discovery of New Microneme Proteins in Cryptosporidium parvum and Implication of the Roles of a Rhomboid Membrane Protein (CpROM1) in Host–Parasite Interaction. Frontiers in Veterinary Science Front Vet Sci. 2021; 8: 778560 WB C. parvum,Human Oocysts, excysted sporozoites

TRPS1 knockdown inhibits angiogenic vascular mimicry in human triple negative breast cancer cells. Clinical & Translational Oncology Clin Transl Oncol. 2022 Jan;24(1):145-153 WB Human MDA-MB-231 cells， sh-NC cells, TRPS1low-siRNA3 cell

Cucurbitacin B inhibits the migration and invasion of breast cancer cells by altering the biomechanical properties of cells. PHYTOTHERAPY RESEARCH Phytother Res. 2019 Mar;33(3):618-630 IHC Mouse 1:500 SKBR-3 cell-xenograft，lung tissue

Effects of enriched environment on depression and anxiety-like behavior induced by early life stress: A comparison between different periods. BEHAVIOURAL BRAIN RESEARCH Behav Brain Res. 2021 Aug;411:113389 WB Mouse 1 : 5000 Hippocampal tissue

Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy Diabet Metab Synd Ob. 2019; 12: 1811–1820 WB,IF Rat 1:100,1:5000 kidney podocytes

Ponicidin inhibits pro-inflammatory cytokine TNF-α-induced epithelial–mesenchymal transition and metastasis of colorectal cancer cells via suppressing the AKT/GSK-3β/Snail pathway. INFLAMMOPHARMACOLOGY Inflammopharmacology. 2019 Jun;27(3):627-638 WB Human 1:10000 HCT116 cell

Blocking MAPK/ERK pathway sensitizes hepatocellular carcinoma cells to temozolomide via downregulating MGMT expression.. Annals of Translational Medicine Ann Transl Med. 2020 Oct; 8(20): 1305 WB Human 1 : 10000 HepG2 cell

Stearidonic acid promotes insulin secretion via stimulation of G protein-coupled receptor 40 in MIN6 pancreatic β-cells. Journal of Functional Foods 2019 Jul 11 WB Mouse MIN6 pancreatic β-cell

Garlic flavonoids alleviate H2O2 induced oxidative damage in L02 cells and induced apoptosis in HepG2 cells by Bcl‐2/Caspase pathway. JOURNAL OF FOOD SCIENCE J Food Sci. 2021 Feb;86(2):366-375 WB Human HepG2 cell

Long non-coding RNA ROR promotes radioresistance in hepatocelluar carcinoma cells by acting as a ceRNA for microRNA-145 to regulate RAD18 expression. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2018 Mar 17 WB Human HepG2 cell,SMMC-7721 cell

Effects of HIF-1α on Spermatogenesis of Varicocele Rats by Regulating VEGF/PI3K/Akt Signaling Pathway. Reproductive Sciences Reprod Sci. 2021 Apr;28(4):1161-1174 WB Rat 1:10000 Testicular tissue

Use of four genes in exosomes as biomarkers for the identification of lung adenocarcinoma and lung squamous cell carcinoma. Oncology Letters Oncol Lett. 2021 Apr;21(4):1-1 WB Human 1:10000 Blood

The expression and prognostic role of EBP1 and relationship with AR in HER2+ breast cancer. VIRCHOWS ARCHIV 2020 Aug;477(2):279-289 WB Human 1:2000 breast cancer (BC) tissue

Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction. BIOSCIENCE REPORTS Bioscience Rep. 2018 Dec;38(6):BSR20180519 WB Rat heart tissues H9c2 cell

Effects of Hydroxysafflor Yellow A on the PI3K/AKT Pathway and Apoptosis of Pancreatic β-Cells in Type 2 Diabetes Mellitus Rats. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy Diabet Metab Synd Ob. 2020; 13: 1097–1107 IHC Rat pancreatic tissues

Autophagy enhanced antitumor effect in K562 and K562/ADM cells using realgar transforming solution. BIOMEDICINE & PHARMACOTHERAPY 2017 Dec 27 IF Human K562 cell

Berberine hydrochloride attenuates lipopolysaccharide-induced endometritis in mice by suppressing activation of NF-κB signal pathway. INTERNATIONAL IMMUNOPHARMACOLOGY 2014 Nov 15 WB Mouse uteri

Effects and Mechanism of Plasma-Activated Medium on Angiogenesis of Vascular Endothelial Cells. Applied Sciences-Basel 2021 Jan;11(20):9603 WB Human 1:5000 HUVECs

The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection. Stem Cell Research & Therapy Stem Cell Res Ther. 2021 Dec;12(1):1-12 WB Pig Liver

Bixin protects against particle-induced long-term lung injury in an NRF2-dependent manner. Toxicology Research 2018 Mar 05 WB Human THP-1 cell

Therapeutic potential of bixin in PM2.5 particles-induced lung injury in an Nrf2-dependent manner. FREE RADICAL BIOLOGY AND MEDICINE Free Radical Bio Med. 2018 Oct;126:166 IF Human BEAS-2B cell

MiR-19a suppress apoptosis of myocardial cells in rats with myocardial ischemia/reperfusion through PTEN/Akt/P-Akt signaling pathway. European Review for Medical and Pharmacological Sciences Eur Rev Med Pharmaco. 2020 Mar;24(6):3322-3330 WB Rat H9c2 cell

Vitamin D protects against particles‐caused lung injury through induction of autophagy in an Nrf2‐dependent manner. ENVIRONMENTAL TOXICOLOGY Environ Toxicol. 2019 May;34(5):594-609 IF Human THP-1 cell,BEAS-2B cell

MiR-335-5p inhibits proliferation of Huh-7 liver cancer cells via targeting the Oct4/Akt pathway.. European Review for Medical and Pharmacological Sciences Eur Rev Med Pharmaco. 2021 Feb;25(4):1853-1860 WB Human Huh7 cell

Silver Nanoparticles Induced Oxidative Stress and Mitochondrial Injuries Mediated Autophagy in HC11 Cells Through Akt/AMPK/mTOR Pathway. BIOLOGICAL TRACE ELEMENT RESEARCH Biol Trace Elem Res. 2021 Mar;199(3):1062-1073 WB Human 1 : 1000 HC11 cell

Zanthoxylum bungeanum Seed Oil Attenuates LPS-Induced BEAS-2B Cell Activation and Inflammation by Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway. Evidence-based Complementary and Alternative Medicine Evid-Based Compl Alt. 2021;2021:2073296 WB Human BEAS-2B cell

LncRNA ROR promotes proliferation of endometrial cancer cells via regulating Notch1 pathway.. European Review for Medical and Pharmacological Sciences Eur Rev Med Pharmaco. 2020 Jun;24(11):5970-5978 WB Human HEC-1A cell

Brucella Outer Membrane Lipoproteins 19 and 16 Differentially Induce Interleukin-18 Response or Pyroptosis in Human Monocytic Cells. JOURNAL OF INFECTIOUS DISEASES J Infect Dis. 2021 Dec;224(12):2148-2159 WB Human THP-1 cells

Curcumin is a Potential Adjuvant to Alleviates Diabetic Retinal Injury via Reducing Oxidative Stress and Maintaining Nrf2 Pathway Homeostasis. Frontiers in Pharmacology Front Pharmacol. 2021 Dec;0:3696 WB Rat 1:5000 Retinal tissue

Modulations of Keap1-Nrf2 signaling axis by TIIA ameliorated the oxidative stress-induced myocardial apoptosis. FREE RADICAL BIOLOGY AND MEDICINE Free Radical Bio Med. 2018 Feb;115:191 IF Mouse Myocardial

Neuroprotective effect of Hongjing I granules on erectile dysfunction in a rat model of bilateral cavernous nerve injury. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2020 Oct;130:110405 WB Rat Penis

Cardiac Glycoside Compound Isolated from Helleborus thibetanus Franch Displays Potent Toxicity against HeLa Cervical Carcinoma Cells through ROS-Independent Autophagy. CHEMICAL RESEARCH IN TOXICOLOGY Chem Res Toxicol. 2019;32(12):2479–2487 WB Human HeLa cell

Pyrotinib treatment on HER2-positive gastric cancer cells promotes the released exosomes to enhance endothelial cell progression, which can be counteracted by apatinib. OncoTargets and Therapy Oncotargets Ther. 2019; 12: 2777–2787 WB Human 1:5000 SGC7901 cell, MGC-803 cell, BGC823 cell, AGS cell,MKN45 cell,NCI-N87 cell

hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR‐139‐3p/CCL5 axis. CANCER SCIENCE Cancer Sci. 2022 Feb; 113(2): 634–647 WB Human HCC cell

Chronic CagA‐positive Helicobacter pylori infection with MNNG stimulation synergistically induces mesenchymal and cancer stem cell‐like properties in gastric mucosal epithelial cells. JOURNAL OF CELLULAR BIOCHEMISTRY J Cell Biochem. 2019 Oct;120(10):17635-17649 WB Human GES-1 cell

Lycium barbarum Polysaccharides Protect Rat Corneal Epithelial Cells against Ultraviolet B-Induced Apoptosis by Attenuating the Mitochondrial Pathway and Inhibiting JNK Phosphorylation. Biomed Research International Biomed Res Int. 2017;2017:5806832 WB Rat 1 : 5000 RCE cell

Lactoferrin suppresses lipopolysaccharide-induced endometritis in mice via down-regulation of the NF-κB pathway. INTERNATIONAL IMMUNOPHARMACOLOGY Int Immunopharmacol. 2015 Sep;28:695 WB Mouse 1:3000 uterine tissues

Pink1/PARK2/mROS-Dependent Mitophagy Initiates the Sensitization of Cancer Cells to Radiation. Oxidative Medicine and Cellular Longevity Oxid Med Cell Longev. 2021;2021:5595652 WB Human HeLa cell， MCF-7 cell

ROS Induced by KillerRed Targeting Mitochondria (mtKR) Enhances Apoptosis Caused by Radiation via Cyt c/Caspase-3 Pathway. Oxidative Medicine and Cellular Longevity Oxid Med Cell Longev. 2019;2019:4528616 WB Human 1 : 1000 HeLa cell

Realgar transforming solution-induced differentiation of NB4 cell by the degradation of PML/RARα partially through the ubiquitin–proteasome pathway. ARCHIVES OF PHARMACAL RESEARCH Arch Pharm Res. 2019 Aug;42(8):684-694 WB Human 1: 5000 NB4 cell

Liver Expression of IGF2 and Related Proteins in ZBED6 Gene-Edited Pig by RNA-Seq. Animals Animals-Basel. 2020 Nov;10(11):2184 WB Pig Liver,spleen,heart,semitendinosus,semimembranosus

Ammonia induces autophagy via circ-IFNLR1/miR-2188-5p/RNF182 axis in tracheas of chickens. BIOFACTORS 2021 Oct 15 WB Chickens 1:8000 Tracheas LMH cells

SPARC ectopic overexpression inhibits growth and promotes programmed cell death in acute myeloid leukemia transformed from myelodysplastic syndrome cells, alone and in combination with Ara-C treatment. ONCOLOGY REPORTS 2015 Sep 01 WB Human 1:1,000 SKM-1 cell

CXCL2 benefits acute myeloid leukemia cells in hypoxia. International Journal of Laboratory Hematology Int J Lab Hematol. 2021 Oct;43(5):1085-1092 WB Human 1:5000 THP-1cell， HL-60 cell

Pig lung fibrosis is active in the subacute CdCl2 exposure model and exerts cumulative toxicity through the M1/M2 imbalance. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Ecotox Environ Safe. 2021 Dec;225:112757 WB Pig 1:10000 Lung

Yeast Selenium Exerts an Antioxidant Effect by Regulating the Level of Selenoprotein to Antagonize Cd-Induced Pyroptosis of Chicken Liver. BIOLOGICAL TRACE ELEMENT RESEARCH Biol Trace Elem Res. 2021 Oct;:1-10 WB Chicken 1:10000 Liver

Pharmaceutic application of vitamin D3 on particle-induced fibrotic effects through induction of Nrf2 signals. Toxicology Research 2020 Apr 24 IF Human BEAS-2B cell,HFLIII cell

Glyphosate induces lymphocyte cell dysfunction and apoptosis via regulation of miR-203 targeting of PIK3R1 in common carp (Cyprinus carpio L.). FISH & SHELLFISH IMMUNOLOGY Fish Shellfish Immun. 2020 Jun;101:51 WB Fish 1:8000 lymphocytes

Hypoxia–CXCL6 axis affects arteriolar niche remodeling in acute myeloid leukemia:. EXPERIMENTAL BIOLOGY AND MEDICINE Exp Biol Med. 2020;246(1):84-96 WB Human 1:5000 MSCs , HUAECs

The preparation of a cold-water soluble polysaccharide from Grifola frondosa and its inhibitory effects on MKN-45 cells. GLYCOCONJUGATE JOURNAL 2020 Jun 15 WB Human MKN-45 cell

Hypoxia–CXCL6 axis affects arteriolar niche remodeling in acute myeloid leukemia:. EXPERIMENTAL BIOLOGY AND MEDICINE Exp Biol Med. 2020;246(1):84-96 WB Human 1:5000 MSCs , HUAECs

Intracellular ion and protein nanoparticle-induced osmotic pressure modify astrocyte swelling and brain edema in response to glutamate stimuli. Redox Biology Redox Biol. 2019 Feb;21:101112 WB Rat Astrocyte

Glycyrrhizic acid attenuates the inflammatory response after spinal cord injury by inhibiting HMGB1 through the p38/JNK signaling pathway. World Neurosurgery World Neurosurg. 2021 Nov;: WB Rat 1:10000 Spinal cord tissue Highly aggressively proliferating immortalized (HAPI) cells

Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis. Molecular Medicine Reports 2020 Aug 19 WB Rat 1 : 8000 Brain

Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2019 Apr;112:108669 WB Mouse Primary murine lung fibroblasts (PMLFs)

HIV p17 enhances T cell proliferation by suppressing autophagy through the p17‐OLA1‐GSK3β axis under nutrient starvation. JOURNAL OF MEDICAL VIROLOGY J Med Virol. 2021 Jun;93(6):3607-3620 WB Human Jurkat cell

Protective Effect of Adipose-Derived Mesenchymal Stem Cell Secretome against Hepatocyte Apoptosis Induced by Liver Ischemia-Reperfusion with Partial Hepatectomy Injury. Stem Cells International Stem Cells Int. 2021;2021:9969372 WB Pig Liver

TRIM59 as a novel molecular biomarker to predict the prognosis of patients with NSCLC. Oncology Letters 2019 Dec 10 IHC Human 1:500 NSCLC tissue

Edaravone improves intermittent hypoxia-induced cognitive impairment and hippocampal damage in rats. BIOLOGICAL & PHARMACEUTICAL BULLETIN 2020 May 30 WB Rat 1:5000 Hippocampal tissue

Dehydrocorydaline Accounts the Majority of Anti-Inflammatory Property of Corydalis Rhizoma in Cultured Macrophage. Evidence-based Complementary and Alternative Medicine Evid-Based Compl Alt. 2020;2020:4181696 WB Mouse 1:5000 RAW 264.7 cell

Ginsenoside Rg1 Alleviates Podocyte Injury Induced by Hyperlipidemia via Targeting the mTOR/NF-κB/NLRP3 Axis. Evidence-based Complementary and Alternative Medicine Evid-Based Compl Alt. 2020;2020:2735714 WB Rat 1 : 5000 Renal tubule，Kidney Podocyte

Radix Angelica Sinensis and Radix Hedysari Ultrafiltration Extract Protects against X-Irradiation-Induced Cardiac Fibrosis in Rats. Evidence-based Complementary and Alternative Medicine Evid-Based Compl Alt. 2020;2020:4675851 WB Rat cardiac fibroblasts

Effect of KLF17 overexpression on epithelial–mesenchymal transition of gastric cancer cells:. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH J Int Med Res. 2021;49(11): IHC Human 1:5000 Gastric cancer , adjacent normal tissue

miR-128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF-C upregulation. Oncology Letters 2015 Sep 09 WB Human 1:1000 SV-HUC-1 cell,T24 cell, 5637 cell

Treadmill Exercise Attenuates Cerebral Ischemia–Reperfusion Injury by Promoting Activation of M2 Microglia via Upregulation of Interleukin-4. Frontiers in Cardiovascular Medicine Front Cardiovasc Med. 2021 Oct;0:1282 WB Rat 1:10000 Penumbra

Salidroside Improves Chronic Stress Induced Depressive Symptoms Through Microglial Activation Suppression. Frontiers in Pharmacology Front Pharmacol. 2021 Jun;0:1442 IF Mouse Brain Primary microglia cells

Down-regulation of RCC1 sensitizes immunotherapy by up-regulating PD-L1 via p27kip1/CDK4 axis in non-small cell lung cancer. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE J Cell Mol Med. 2021 Apr;25(8):4136-4147 WB Human 1:10000 A549 cell，H1299 cell

Inhibition of Uncoupling Protein 2 Enhances the Radiosensitivity of Cervical Cancer Cells by Promoting the Production of Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity Oxid Med Cell Longev. 2020;2020:5135893 WB Human 1 : 10000 HeLa cell

Kaempferol potentiates the sensitivity of pancreatic cancer cells to erlotinib via inhibition of the PI3K/AKT signaling pathway and epidermal growth factor receptor. INFLAMMOPHARMACOLOGY Inflammopharmacology. 2021 Oct;29(5):1587-1601 WB Human PANC-1，BxPC-3

Rapamycin inhibits proliferation and apoptosis of retinoblastoma cells through PI3K/AKT signaling pathway. Oncology Letters Oncol Lett. 2020 Apr;19(4):2950-2956 WB Human Y79 cell

Inhibitory effects of alkaline extract from the pericarp of Citrus reticulata Blanco on collagen behavior in bleomycin-induced pulmonary fibrosis. JOURNAL OF ETHNOPHARMACOLOGY J Ethnopharmacol. 2021 Apr;269:113761 IHC,WB Mouse 1:1000 Lung

Chlorpyrifos triggers epithelioma papulosum cyprini cell pyroptosis via miR-124-3p/CAPN1 axis. JOURNAL OF HAZARDOUS MATERIALS J Hazard Mater. 2022 Feb;424:127318 WB Fish 1:10000 Epithelioma papulosum cyprini (EPC) cell

Lysine crotonylation of DgTIL1 at K72 modulates cold tolerance by enhancing DgnsLTP stability in chrysanthemum. PLANT BIOTECHNOLOGY JOURNAL Plant Biotechnol J. 2021 Jun; 19(6): 1125–1140 WB Chrysanthemum，Tobacco 1:10000 Leaves

Function of Chick Subcutaneous Adipose Tissue During the Embryonic and Posthatch Period. Frontiers in Physiology Front Physiol. 2021; 12: 684426 WB Chicken Adipose，liver

Effect of metformin on apoptosis, cell cycle arrest migration and invasion of A498 cells. Molecular Medicine Reports 2014 Mar 31 WB Human A498 cell

Effects of DHA dietary intervention on hepatic lipid metabolism in apolipoprotein E-deficient and C57BL/6J wild-type mice. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2021 Dec;144:112329 IHC Mouse Liver

The tissue expression level of BPI gene in piglets from newborn to weaning and its relationship with Gram-negative bacterial infection. Journal of Integrative Agriculture J Integr Agr. 2020 Dec;19:3065 WB Pig 1:5000 IPEC-J2 cells

Li, Xiaojing, et al. "Selenoprotein S silencing triggers mouse hepatoma cells apoptosis and necrosis involving in intracellular calcium imbalance and ROS-mPTP-ATP." Biochimica et Biophysica Acta (BBA)-General Subjects1862.10 (2018): 2113-2123.

Qian, Fuliang, et al. "MiR‐378a‐3p as a putative biomarker for hepatocellular carcinoma diagnosis and prognosis: Computational screening with experimental validation." Clinical and translational medicine 11.2 (2021): e307.

Zeng, Xiaozhu, et al. "Down‐regulation of RCC1 sensitizes immunotherapy by up‐regulating PD‐L1 via p27kip1/CDK4 axis in non‐small cell lung cancer." Journal of cellular and molecular medicine 25.8 (2021): 4136-4147.

Zhang, Yanyan, et al. "Salidroside Ameliorates Vascular Endothelial Cell Senescence through Downregulation of KLF4." Journal of Biosciences and Medicines 9.2 (2021): 21-32.

Ding, Xuedong, et al. "Chicken serum uric acid level is regulated by glucose transporter 9." Animal Bioscience 34.4 (2021): 670.

Mi, Youjun, et al. "Production of SARS-CoV-2 virus-like particles in insect cells." Vaccines 9.6 (2021): 554.

Xin, Weijuan, et al. "lncRNA LA16c‑313D11. 11 modulates the development of endometrial cancer by binding to and inhibiting microRNA‑205‑5p function and indirectly increasing PTEN activity." International journal of oncology 57.1 (2020): 355-363.

Immunoway Biotech, China

王万林, et al. "艾纳香油对 NF-κB 及 Nrf2/HO-1 信号通路的作用研究." 畜牧兽医学报 52.4 (2021): 976-986.

司晓丽, et al. "芍药苷对 DSS 诱导大鼠慢性溃疡性结肠炎 IL-17 表达的影响." 中国免疫学杂志 37.08: 946.

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Losartan protects against intermittent hypoxia-induced peritubular capillary loss by modulating the renal renin–angiotensin system and angiogenesis factors. ACTA BIOCHIMICA ET BIOPHYSICA SINICA Acta Bioch Bioph Sin. 2020 Jan;52(1):38-48 WB Rat 1:10000 Kidney cortex

Cadmium exposure causes mitochondrial fission and fusion disorder in the pig hypothalamus via the PI3K/AKT pathway ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Shiwen Xu WB Pig

Phenylpropenol ester and sesquiterpenoids with antimetastatic activities from the whole plants of Chloranthus japonicus Arabian Journal of Chemistry Fubo Zhang WB Human

Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway Frontiers in Endocrinology Rui-Rui Wang WB Mouse

Flavonoid Group of Smilax glabra Roxb. Regulates the Anti-Tumor Immune Response Through the STAT3/HIF-1 Signaling Pathway Frontiers in Pharmacology Qiyang Shou WB Mouse

A novel heterozygous variant in PANX1 is associated with oocyte death and female infertility JOURNAL OF ASSISTED REPRODUCTION AND GENETICS Jun Tan WB Human

Caffeine Decreases Hepcidin Expression to Alleviate Aberrant Iron Metabolism under Inflammation by Regulating the IL-6/STAT3 Pathway Life-Basel Zhong-Da Li WB Mouse

Gluconeogenesis Alteration and p53-SIRT6-Fox01 Signaling Adaptive Regulation in Sheep from Different Grazing Periods Computational and Mathematical Methods in Medicine Jinling Cao WB Sheep

Histatin-1 alleviates high-glucose injury to skin keratinocytes through MAPK signaling pathway Journal of Cosmetic Dermatology Xuanfen Zhang MD WB Human

LncRNA GAS6-AS1 facilitates tumorigenesis and metastasis of colorectal cancer by regulating TRIM14 through miR-370-3p/miR-1296-5p and FUS Journal of Translational Medicine Jie Wu WB Human

Protective effect of adipose-derived stromal cell-secretome attenuate autophagy induced by liver ischemia–reperfusion and partial hepatectomy Stem Cell Research & Therapy Hongbin Wang WB Pig

Network Pharmacology, Molecular Docking, and Experimental Validation to Unveil the Molecular Targets and Mechanisms of Compound Fuling Granule to Treat Ovarian Cancer Oxidative Medicine and Cellular Longevity Fangfang Tao WB Human

Vitamin D protects silica particles induced lung injury by promoting macrophage polarization in a KLF4-STAT6 manner JOURNAL OF NUTRITIONAL BIOCHEMISTRY Shasha Tao WB Human,Mouse

Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice. Frontiers in Pharmacology Hong Zhou IHC Mouse

Comprehensive analysis of ferroptosis-related gene signatures as a potential therapeutic target for acute myeloid leukemia: A bioinformatics analysis and experimental verification Frontiers in Oncology Donghong Lin WB Human

Acute hypoxia promotes the liver angiogenesis of largemouth bass (Micropterus salmoides) by HIF - Dependent pathway FISH & SHELLFISH IMMUNOLOGY Liulan Zhao WB Fish

ROS-mediated PPAR/RXR inhibition contributes to acetochlor-induced apoptosis and autophagy in Ctenopharyngodon idella hepatic cells FISH & SHELLFISH IMMUNOLOGY Yuhong Yang WB Fish

Electroacupuncture of Baihui and Shenting ameliorates cognitive deficits via Pten/Akt pathway in a rat cerebral ischemia injury model. Frontiers in Neurology Xiaodong Feng WB Rat

MiR-942-5p targeting the IFI27 gene regulates HCT-8 cell apoptosis via a TRAIL-dependent pathway during the early phase of Cryptosporidium parvum infection Parasites & Vectors Longxian Zhang WB Human

Mitochondrial-Targeting Vitamin B3 Ameliorates the Phenotypes of Parkinson's Disease In Vitro and In Vivo by Restoring Mitochondrial Function Advanced Therapeutics Hua Bai WB Human

Eucalyptol relieves the toxicity of diisobutyl phthalate in Ctenopharyngodon idellus kidney cells through Keap1/Nrf2/HO-1 pathway: Apoptosis-autophagy crosstalk and immunoregulation FISH & SHELLFISH IMMUNOLOGY Min Liu WB Fish

Paraquat induces apoptosis, programmed necrosis, and immune dysfunction in CIK cells via the PTEN/PI3K/AKT axis FISH & SHELLFISH IMMUNOLOGY Xiaojing Li WB Fish

ANGPTL3 is involved in kidney injury in high-fat diet-fed mice by suppressing ACTN4 expression Lipids in Health and Disease Xia Gao IHC Mouse

Barrigenol-like triterpenoid saponins from the husks of Xanthoceras sorbifolia bunge and their anti-inflammatory activity by inhibiting COX-2 and iNOS expression PHYTOCHEMISTRY Dali Meng WB Mouse

Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage JOURNAL OF BONE AND MINERAL METABOLISM Jian Sun WB Human

Distribution characteristics and regulation of amino acids and fatty acids in muscle and adipose tissues of sheep grown in natural grazing environment ANIMAL SCIENCE JOURNAL Jinling Cao WB Sheep

Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes

Platelet membrane-camouflaged nanoparticles carry microRNA inhibitor against myocardial ischaemia‒reperfusion injury

Highly Stable Fibronectin-mimetic-peptide-based Supramolecular Hydrogel to Accelerate Corneal Wound Healing Acta Biomaterialia Jiaqing Wang WB Human human corneal epithelial cells (HCECs)

Hesperidin inhibits lung fibroblast senescence via IL-6/STAT3 signaling pathway to suppress pulmonary fibrosis PHYTOMEDICINE Fanchao Feng WB Mouse Lung tissue

New Insights into How Melatonin Ameliorates Bisphenol A-Induced Colon Damage: Inhibition of NADPH Oxidase JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Shiwen Xu WB Mouse,Human colon tissue NCM460 cells

Vorapaxar proven to be a promising candidate for pulmonary fibrosis by intervening in the PAR1/JAK2/STAT1/3 signaling pathway-an experimental in vitro and vivo study EUROPEAN JOURNAL OF PHARMACOLOGY Ting Xiao WB Mouse,Human lung tissue MLG cells,HFL1 cells

Identification and Validation of a Novel Prognostic Signature Based on Ferroptosis-Related Genes in Ovarian Cancer Vaccines Huichao Huang WB Human Ovarian cancer (OC) cells

Protective effect of astaxanthin on tuberculosis-associated inflammatory lung injury EXPERIMENTAL BIOLOGY AND MEDICINE Xiaoguang Zou WB Mouse MLE-12 cells

CMTM7 inhibits breast cancer progression by regulating Wnt/β-catenin signaling BREAST CANCER RESEARCH Yue Yu CoIP Human MCF-7 cell

CHIR99021 Maintenance of the Cell Stemness by Regulating Cellular Iron Metabolism Antioxidants Yan-Zhong Chang WB Mouse Neuro-2a cell

Ameliorative effects of different doses of selenium against fluoride-triggered apoptosis and oxidative stress-mediated renal injury in rats through the activation of Nrf2/HO-1/NQO1 signaling pathway FOOD AND CHEMICAL TOXICOLOGY Jinming Wang IHC,IF Rat kidney

Inactivation of microglia dampens blood-brain barrier permeability and loss of dopaminergic neurons in paraquat-lesioned mice FOOD AND CHEMICAL TOXICOLOGY Xiao-Feng Zhang WB Mouse midbrain

Baricitinib Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice by Inhibiting TGF-β1 Signaling Pathway MOLECULES Cheng Yang WB Mouse,Human lung tissues Mlg cell,NIH−3T3 cell,A549 cell, MLE12 cell

ROS mediated pyroptosis-M1 polarization crosstalk participates in inflammation of chicken liver induced by bisphenol A and selenium deficiency ENVIRONMENTAL POLLUTION Shiwen Xu WB Chicken liver Chicken liver cancer (LMH) cell ,chicken macrophages (HD11)cell

A Liquid–Liquid Phase Separation-Related Index Associate with Biochemical Recurrence and Tumor Immune Environment of Prostate Cancer Patients INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Ning Xu WB Human prostate cancer (PCa)cell

TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo ARTHRITIS RESEARCH & THERAPY Lin Huang IHC Rat disc samples

Clinopodium chinense Kuntze ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by reducing systematic inflammation and regulating metabolism JOURNAL OF ETHNOPHARMACOLOGY Dali Meng WB Mouse colon RAW264.7 cell

Euphohelides A–C, ent-Abietane-Type Norditerpene Lactones from Euphorbia helioscopia and Their Anti-Inflammatory Activities JOURNAL OF NATURAL PRODUCTS Kun Gao WB Mouse RAW264.7 cell

Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice BIOLOGICAL TRACE ELEMENT RESEARCH Sun, Zilong WB Mouse liver tissues

Effectiveness of fractional carbon dioxide laser combined with botulinum toxin type A in a rabbit ear model with the underlying mechanism Journal of Cosmetic Dermatology Huicai Wen IHC,WB Rabbit scar tissues

Ameliorating role of Tetrastigma hemsleyanum polysaccharides in antibiotic-induced intestinal mucosal barrier dysfunction in mice based on microbiome and metabolome analyses INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Zhishan Ding WB,IHC Mouse colon tissue

Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress Antioxidants Hong Zhou WB Mouse,Rat kidney NRK-52E cell

The pathological significance and potential mechanism of ARHGEF6 in lung adenocarcinoma COMPUTERS IN BIOLOGY AND MEDICINE Shikang Li WB Human A549 cell

Glucose-driven transformable complex eliminates biofilm and alleviates inflamm-aging for diabetic periodontitis therapy. Bin Liu WB Mouse 1:5000 RAW264.7 ​cell

Lysine malonylation of DgnsLIPID TRANSFER PROTEIN1 at the K81 site improves cold resistance in chrysanthemum. Qinglin Liu WB Dendranthema grandiflorum chrysanthemum leave

Guiqi Baizhu prescription ameliorates cytarabine-induced intestinal mucositis by targeting JAK2 to inhibit M1 macrophage polarization. Yong-qi Liu WB Mouse 1:5000 ileal tissue M1 macrophage (M1)

Astragaloside IV ameliorates radiation-induced nerve cell damage by activating the BDNF/TrkB signaling pathway. Baoping Shao WB Mouse 1:10000 brain tissue PC12 cell,primary cortical neurons

Increased abundance of bacteria of the family Muribaculaceae achieved by fecal microbiome transplantation correlates with the inhibition of kidney calcium oxalate stone deposition in experimental rats. Pan TieJun IHC Rat 1:200 kidney tissue

Echinacea Polyphenols Inhibit NLRP3-Dependent Pyroptosis, Apoptosis, and Necroptosis via Suppressing NO Production during Lipopolysaccharide-Induced Acute Lung Injury. Xiaoqiang Liu WB Mouse 1:5000 lung tissue A549 cell

To study the protective effect of Huangqi Baihe Granules on Radiation brain injury based on network pharmacology and experiment. Yongqi Liu WB Rat 1:5000 brain tissue

Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury. Baofei Sun WB Mouse 1:10000 BV2 cell

Dexmedetomidine attenuates sleep deprivation-induced inhibition of hippocampal neurogenesis via VEGF-VEGFR2 signaling and inhibits neuroinflammation. Qian Zhai WB Mouse 1:10000 Hippocampal tissue

Acute myeloid leukemia (AML)-derived mesenchymal stem cells induce chemoresistance and epithelial–mesenchymal transition-like program in AML through IL-6/JAK2/STAT3 signaling. Li Zhao WB Human 1:5000 K562 cell,HL60 cell

Deciphering the function of Xiangsha-Liujunzi-Tang in enhancing duodenal mucosal barrier by inhibiting MC/Tryptase/PAR-2 signaling pathway in functional dyspepsia rats. Yingxia Cheng WB Rat 1:5000 duodenal tissue

Integrated Single-Cell and Transcriptome Sequencing Analyses Identify Dipeptidase 2 as an Immune-Associated Prognostic Biomarker for Lung Adenocarcinoma. Yongheng Chen IHC Human 1:1000 Lung adenocarcinoma (LUAD) tissue

Intestinal microbiota regulates colonic inflammation in fluorosis mice by TLR/NF-κB pathway through short-chain fatty acids. Zilong Sun WB Mouse 1:10000 colon tissue

LRRC8A promotes the initial development of oxaliplatin resistance in colon cancer cells. Liangming Li WB Human 1:5000 HCT116 cell,R-Oxa cell

Dangshen Huangjiu exerts prevention of gastric mucosal injury and inhibits Akt/NF-κB signaling. Fangdi Hu WB Rat,Human gastric mucosal tissues GES-1 cell

Retinoid X receptor agonists alleviate fibroblast activation and post-infarction cardiac remodeling via inhibition of TGF-β1/Smad pathway. Da-jun Chai WB Rat heart

Overexpression of POLA2 in hepatocellular carcinoma is involved in immune infiltration and predicts a poor prognosis. Xuequan Wang WB Human Hepatocellular carcinoma (HCC) tissues HepG2 cell, SMMC-7721 cell

Type 2 innate lymphoid cell-derived amphiregulin regulates type II alveolar epithelial cell transdifferentiation in a mouse model of bronchopulmonary dysplasia. Hong-yan Lu WB Mouse 1:5000 lung MLE-12 cell

TRIM50 inhibits gastric cancer progression by regulating the ubiquitination and nuclear translocation of JUP. Shuqiang Yuan WB Human gastric cancer tissues MKN45 cell,SNU-668 cell

A tumor-associated macrophages related model for predicting biochemical recurrence and tumor immune environment in prostate cancer. Ning Xu WB Human 1:10000 DU145 cell, PC-3 cell,22RV1 cell

Dietary antioxidant quercetin overcomes the acquired resistance of Sorafenib in Sorafenib-resistant hepatocellular carcinoma cells through epidermal growth factor receptor signaling inactivation. Zhou Fuqiong WB Mouse，Human 1:10000 Huh7 cell-xenograft Huh7 cell

High-protein compound yogurt with quinoa improved clinical features and metabolism of high-fat diet–induced nonalcoholic fatty liver disease in mice. Lin Wang WB Mouse 1:2000 liver, ileal

MiR-3976 regulates HCT-8 cell apoptosis and parasite burden by targeting BCL2A1 in response to Cryptosporidium parvum infection. Rongjun Wang WB Human 1:5000 HCT-8 cell

LIF regulates the expression of miR-27a-3p and HOXA10 in bovine endometrial epithelial cells via STAT3 pathway. Peng Zheng WB Bovine 1:10000 bovine endometrial epithelial cells (BEECs)

Critical role of MXRA7 in differentiation blockade in human acute promyelocytic leukemia cells. Yiqiang Wang WB Human human acute promyelocytic leukemia (APL) samples MOLM-13 cell, MEG01 cell, MV-411 cell,NB4 cell

TBBPA causes apoptosis in grass carp hepatocytes involving destroyed ER-mitochondrial function. CHEMOSPHERE Shiwen Xu WB Fish 1:8000 L8824 cell

A novel CD8+ T cell-related gene signature for predicting the prognosis and immunotherapy efficacy in bladder cancer. INFLAMMATION RESEARCH Xu Ning WB Human 1:1000 5637 cell,T24 cell,UMUC-3 cell,SV-HUC-1 cell

Gastroprotective effect of eupatilin, a polymethoxyflavone from Artemisia argyi H.Lév. & Vaniot, in ethanol-induced gastric mucosal injury via NF-κB signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY Dali Meng WB Mouse，Rat gastric tissues RAW264.7 cell

Flavokawain A ameliorates pulmonary fibrosis by inhibiting the TGF-β signaling pathway and CXCL12/CXCR4 axis. EUROPEAN JOURNAL OF PHARMACOLOGY Cheng Yang WB Mouse lung tissues Mlg cell

Evodiamine alleviates DEHP-induced hepatocyte pyroptosis, necroptosis and immunosuppression in grass carp through ROS-regulated TLR4 / MyD88 / NF-κB pathway. FISH & SHELLFISH IMMUNOLOGY Hongjin Lin WB Fish 1:10000 L8824 cell

Circadian rhythm disturbances involved in ozone-induced glucose metabolism disorder in mouse liver. SCIENCE OF THE TOTAL ENVIRONMENT Guohua Qin WB Mouse liver

Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress. Cell Death & Disease Fengling Chen IHC Human Liver tissues

Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells. Molecular Oncology Qiaoxia Zhang WB Human OCI/AML3 cell,NB4 cell，MOLM-13 cell

LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes via sponging miR-1934-3p. CELL BIOLOGY AND TOXICOLOGY Xu Shiwen WB Mouse 1:10000 AML-12 cell

Selenium deficiency caused hepatitis in chickens via the miR-138-5p/SelM/ROS/Ca2+ overload pathway induced by hepatocyte necroptosis. Food & Function Jiuli Zhang WB Chicken 1 : 1000 liver LMH cell

Placenta-derived exosomal miR-135a-5p promotes gestational diabetes mellitus pathogenesis by activating PI3K/AKT signalling pathway via SIRT1. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Jianying Yan WB Human plasma，placenta tissue HTR-8/SVneo cell

Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells. BIOORGANIC CHEMISTRY Dali Meng WB Human HCT116 cell

Chlorpyrifos-mediated mitochondrial calcium overload induces EPC cell apoptosis via ROS/AMPK/ULK1. FISH & SHELLFISH IMMUNOLOGY Shiwen Xu WB Fish 1:8000 epithelioma papulosum cyprini (EPC) cell

Exploring the Mechanism of Chuanxiong Rhizoma against Thrombosis Based on Network Pharmacology, Molecular Docking and Experimental Verification. MOLECULES Wenwen Jiang WB Human 1:10000 EA.hy926 cell

Triterpenoids from Meehania fargesii with Cytotoxic Activity1. CHEMISTRY & BIODIVERSITY Dali Meng WB Human HCT116 cell

Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization. Oncology Letters Ke-Xiang Zhu WB Human 1:3000 HPNE cell,PaCa-2 cell, PANC-1 cell, AsPC-1 cell,SW1990 cell

YAP1 affects the prognosis through the regulation of stemness in endometrial cancer. PeerJ Rui Yuan WB Human HEC1-A cell, Ishikawa cell

Fecal microbiota transplantation and short-chain fatty acids improve learning and memory in fluorosis mice by BDNF-PI3K/AKT pathway. CHEMICO-BIOLOGICAL INTERACTIONS Ruiyan Niu WB Mouse 1: 10000 hippocampus

Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc. CELLULAR SIGNALLING Zhimin Yin WB Human MCF-7 cell

Expression and functional analysis of fam76b in zebrafish. FISH & SHELLFISH IMMUNOLOGY Haibin Xia IHC Zebrafish 1:500

Efectos Protectores y Mecanismos de la Decocción de Huangqi Contra los Efectos Secundarios Inducidos por la Radiación. INTERNATIONAL JOURNAL OF MORPHOLOGY WB Rat brain,kidney

Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma Cancer Communications Xiaoteng Cui WB Human 1:10000 TBD0220 cell,U-87 MG cell

BPA and low-Se exacerbate apoptosis and autophagy in the chicken bursa of Fabricius by regulating the ROS/AKT/FOXO1 pathway SCIENCE OF THE TOTAL ENVIRONMENT Wenying Sun WB Chicken 1:10000 Fabricius tissue MDCC-MSB-1 cell

Hexadecanamide alleviates Staphylococcus aureus-induced mastitis in mice by inhibiting inflammatory responses and restoring blood-milk barrier integrity PLoS Pathogens Lijuan Bao WB Mouse 1:20000 mammary gland,colon HC11 cell

Triptolide attenuates CCL4-induced liver fibrosis by regulating the differentiation of CD4+ T cells in mice INTERNATIONAL IMMUNOPHARMACOLOGY Shiyuan Jiang WB Mouse liver tissue

Inhibiting CBP Decreases AR Expression and Inhibits Proliferation in Benign Prostate Epithelial Cells Biomedicines Xingxing Tang WB Human 1:10000 BPH-1 cell,RWPE-1 cell

Profile of the bile acid FXR-FGF15 pathway in the glucolipid metabolism disorder of diabetic mice suffering from chronic stress PeerJ Weijia Cai WB Mouse 1:5000 liver,ileum

The BRAFV600E mutation maintains the aggressiveness of papillary thyroid cancers requiring downregulation of primary cilia MOLECULAR AND CELLULAR ENDOCRINOLOGY Cheng-Xu Ma IF Human 1:200 thyroid tumor tissue

Urinary-derived extracellular vesicle microRNAs as non‐invasive diagnostic biomarkers for early-stage renal cell carcinoma CLINICA CHIMICA ACTA Yu Zhang WB Human 1:6000 urinary-derived extracellular vesicle (uEV)

Increased RBP4 and Asprosin Are Novel Contributors in Inflammation Process of Periodontitis in Obese Rats INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Yuwei Zhang WB Rat 1:10000 gingival tissue

HgCl2 exposure mediates pyroptosis of HD11 cells and promotes M1 polarization and the release of inflammatory factors through ROS/Nrf2/NLRP3 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Jiaqi Wang WB Chicken 1:100000 HD11 cell

Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells iScience Zhe Cheng WB Human Colorectal cancer (CRC) tissue FHC cell,SW480 cell,SW620 cell,HCT116 cell

EphB1 promotes the differentiation and maturation of dendritic cells in non-small cell lung cancer CANCER LETTERS Yaohuan Xie WB Mouse 1:5000 Tumor dendritic cells (DCs)

Protective effects of a novel chimeric virus–like particle vaccine against virulent NDV and IBDV challenge VACCINE Jindou Li WB Spodoptera frugiperda 1:4000 Sf9 cell

Danlou Recipe promotes cholesterol efflux in macrophages RAW264.7 and reverses cholesterol transport in mice with hyperlipidemia induced by P407 BMC Complementary Medicine and Therapies Han Wenrun WB Mouse 1:3000 liver tissue RAW264.7 cell

An investigation of the mechanism of ZiyinDianji decoction in treating follicular dysplasia based on network pharmacology and molecular docking CELLULAR AND MOLECULAR BIOLOGY Xue Feng WB Rat 1:5000 varian tissue

Hypoxia Aggravates Neuron Ferroptosis in Early Brain Injury Following Subarachnoid Hemorrhage via NCOA4-Meditated Ferritinophagy Antioxidants Zixuan Yuan WB Mouse 1:10000 brain tissue HT22 cell

Spinosin inhibits activated hepatic stellate cell to attenuate liver fibrosis by targeting Nur77/ASK1/p38 MAPK signaling pathway EUROPEAN JOURNAL OF PHARMACOLOGY Gang Lin WB Human,Mouse liver tissue LX-2 cell,HSC-T6 cell

Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome Molecular Medicine Reports Congcong Xie WB Human 1:3000 cumulus granulosa cells (cGCs)

Ononin promotes radiosensitivity in lung cancer by inhibiting HIF-1α/VEGF pathway PHYTOMEDICINE Yi-Ming Zhang IF Human 1:4000 NCI-H1299 cell,NCI-A549 cell

Mechanism of NO2-induced migraine in rats: The exploration of the role of miR-653-3p/IGF1 axis JOURNAL OF HAZARDOUS MATERIALS Shuzi Ye WB Rat 1:10000 trigeminal ganglion primary trigeminal ganglion neurons (PTGNs)

Gadolinium Oxide Nanoparticles Reinforce the Fractionated Radiotherapy-Induced Immune Response in Tri-Negative Breast Cancer via cGAS-STING Pathway International Journal of Nanomedicine Boyi Yu WB Mouse 4T1 cell

A GAPDH serotonylation system couples CD8+ T cell glycolytic metabolism to antitumor immunity MOLECULAR CELL Xu Wang WB Mouse 1:10000 CD8+ T cell,EL4 cell

Calcium supplementation attenuates fluoride-induced bone injury via PINK1/Parkin-mediated mitophagy and mitochondrial apoptosis in mice JOURNAL OF HAZARDOUS MATERIALS Yingjun Hu WB Mouse 1:8000 femur tissue

Nano‑selenium alleviates the pyroptosis of cardiovascular endothelial cells in chicken induced by decabromodiphenyl ether through ERS-TXNIP-NLRP3 pathway SCIENCE OF THE TOTAL ENVIRONMENT Yangyang Jiang WB Chicken 1:10000 cardiovascular tissue Chicken arterial endothelial cells (PAECs)

Riboflavin alleviates fluoride-induced ferroptosis by IL-17A-independent system Xc−/GPX4 pathway and iron metabolism in testicular Leydig cells ENVIRONMENTAL POLLUTION Xiang Li WB Mouse 1:5000 TM3 cell

Paracrine signaling of ferroptotic airway epithelium in crystalline silica-induced pulmonary fibrosis augments local fibroblast activation through glycolysis reprogramming ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Qianmin Li WB Mouse,Human lung tissue HBE cell,MRC-5 cell

IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3 MOLECULAR MEDICINE Zhu Ying WB Mouse 1:5000 lung tissue

Huangqi Baihe Granules alleviate hypobaric hypoxia-induced acute lung injury in rats by suppressing oxidative stress and the TLR4/NF-κB/NLRP3 inflammatory pathway JOURNAL OF ETHNOPHARMACOLOGY Yuanding Zeng WB Rat 1:10000 lung tissue

CK1δ/ε inhibition induces ULK1-mediated autophagy in tumorigenesis Translational Oncology Vivian Weiwen Xue WB Human A549 cell,HEK293 cell

NS1: A Promising Novel Target Antigen with Strong Immunogenicity and Protective Efficacy for Avian Flavivirus Vaccine Development POULTRY SCIENCE Juan Huang WB Duck 1:5000 Duck embryo fibroblasts (DEFs)

The plasma derived exosomal miRNA-483-5p/502-5p serve as potential MCI biomarkers in aging EXPERIMENTAL GERONTOLOGY Ting Liu WB Human plasma

Cadmium Exposure Induces Apoptosis and Necrosis of Thyroid Cells via the Regulation of miR-494-3p/PTEN Axis BIOLOGICAL TRACE ELEMENT RESEARCH Zhao Jinghua WB Pig 1:10000 thyroid tissue

Lamin B1: a novel biomarker in adult and pediatric adrenocortical carcinoma ENDOCRINE-RELATED CANCER Yihao Chen WB Human 1:5000 SW13 cell,H295R cell

Exercise Alleviates Fluoride-Induced Learning and Memory Impairment in Mice: Role of miR-206-3p and PREG BIOLOGICAL TRACE ELEMENT RESEARCH Chai Lei WB Mouse 1:10000 HT-22 cell

The effect and mechanism of selenium supplementation on the proliferation capacity of bovine endometrial epithelial cells exposed to lipopolysaccharide in vitro under high cortisol background JOURNAL OF ANIMAL SCIENCE Li Hanqing WB Bovine bovine endometrial epithelial cells (BEECs)

Methionine enkephalin (MENK) protected macrophages from ferroptosis by downregulating HMOX1 and ferritin Proteome Science Tian Jing WB Mouse 1:10000 RAW264.7 cell

STMN1 Promotes Tumor Metastasis in Non-small Cell Lung Cancer Through Microtubule-dependent And Nonmicrotubule-dependent Pathways International Journal of Biological Sciences Lizhong Zeng ICC Human 1:500 NCI-H1299 cell,PC-9 cell

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells Cell Death & Disease Dou Zhihui WB Human 1:10000 Human glioma stem cell-like cells (GSCS),A172 cell,T98G cell,U251 cell,U87 cell,HA1800 cell

9-O-monoethyl succinate berberine effectively blocks the PI3K/AKT signaling pathway by targeting Wnt5a protein in inhibiting osteosarcoma growth PHYTOMEDICINE Yanquan Wang WB Mouse,Human 143B cell,HOS cell,bone marrow mesenchymal stem cells (BMSCs)

LRRC8A as a central mediator promotes colon cancer metastasis by regulating PIP5K1B/PIP2 pathway BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE Haifeng Zhang WB Human 1:5000 HCT116 cell

Apical papilla stem cell-derived exosomes regulate lipid metabolism and alleviate inflammation in the MCD-induced mouse NASH model BIOCHEMICAL PHARMACOLOGY Yi-Fei Nie WB Mouse 1:10000 liver tissue exosomes

Nrf2-mediated redox balance alleviates LPS-induced vascular endothelial cell inflammation by inhibiting endothelial cell ferroptosis Scientific Reports Hou Huimin WB Human 1:5000 Human umbilical vein endothelial cells (HUVEC)

An Inulin-Type Fructan CP-A from Codonopsis pilosula Alleviated 5-Fluorouracil-Induced Intestinal Mucositis via the ERK/MLCK/MLC2 Pathway and Regulation of Gut Microbiota Pharmaceuticals Jiangtao Zhou IHC,WB Rat small-intestine tissues IEC-6 cell

Alpha-fetoprotein upregulates hepatocellular carcinoma cell-intrinsic PD-1 expression through the LATS2/YAP/TEAD1 pathway BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS Guangxian Leng WB,IF Human 1:5000,1:5000 LO2 cell,HLE cell,Huh-7 cell,Hep3B cell,SNU182 cell

Riboflavin Attenuates Fluoride-Induced Testicular Injury via Interleukin 17A-Mediated Classical Pyroptosis JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Xiang Li WB Mouse 1:5000 testicular tissue TM3 cell

Unraveling the immune landscape and therapeutic biomarker PMEPA1 for oxaliplatin resistance in colorectal cancer: A comprehensive approach BIOCHEMICAL PHARMACOLOGY Zhengguang Zhang WB Mouse,Human 1:10000 HCT116R cell-Xenograft HCT116 cell

Protective Effect of Mesenchymal Stem Cell Active Factor Combined with Alhagi maurorum Extract on Ulcerative Colitis and the Underlying Mechanism INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Xuanhong Cao WB Mouse 1:3000 colon tissue

Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes EUROPEAN JOURNAL OF PHARMACOLOGY Lei Zhu WB Mouse B16 cell-Xenograft B16 cell,MC38 cell

Exploring the Role of the CapG Gene in Hypoxia Adaptation in Tibetan Pigs Frontiers in Genetics Yan Feifei WB Pig 1:10000 lung tissue

IRF4-mediated Treg phenotype switching can aggravate hyperoxia-induced alveolar epithelial cell injury BMC Pulmonary Medicine Langyue He WB Mouse 1:5000 lung tissue

A novel multifunctional microneedle patch for synergistic photothermal- gas therapy against maxillofacial malignant melanoma and associated skin defects JOURNAL OF NANOBIOTECHNOLOGY Shaojie Dong WB Mouse 1:5000 novel multifunctional sodium nitroprusside and Fe2+ ions loaded microneedles (SNP-Fe@MNs)

Lithium-Doped Titanium Dioxide-Based Multilayer Hierarchical Structure for Accelerating Nerve-Induced Bone Regeneration ACS Applied Materials & Interfaces Qianqian Zhang WB Mouse,Human 1:10000 MC3T3-E1 cell,Schwann cell (SC),human umbilical vein endothelial cell(HUVEC)

Modulation of epithelial-mesenchymal transition by gemcitabine: Targeting ionizing radiation-induced cellular senescence in lung cancer cell BIOCHEMICAL PHARMACOLOGY Heng Zhou WB Mouse,Human A549 cell,PC-9 cell,Lewis lung carcinoma cell

Co-exposure of decabromodiphenyl ethane and polystyrene nanoplastics damages grass carp (Ctenopharyngodon idella) hepatocytes: Focus on the role of oxidative stress, ferroptosis, and inflammatory reaction SCIENCE OF THE TOTAL ENVIRONMENT Bendong Shi WB Fish Ctenopharyngodon idella hepatocytes (L8824 cells)

Treponema pallidum recombinant protein Tp0768 enhances the ability of HUVECs to promote neutrophil chemotaxis through TLR2/ER stress signaling pathway JOURNAL OF LEUKOCYTE BIOLOGY Cao Ting WB Human 1:2000 human umbilical vein endothelial cells (HUVECs)

GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB JOURNAL OF VIROLOGY Xiaoran Chang WB Human,Monkey Vero cell,293T cell

The FGF6 amplification mutation plays an important role in the progression and treatment of malignant meningioma Translational Oncology Ruihao Liang WB Human 1:10000 IOMM-LEE cell,CH157MN cell

Clcn3 deficiency ameliorates high-fat diet-induced obesity and improves metabolism in mice Frontiers in Nutrition Duan Sirui WB Mouse adipose tissue

Elucidating the mechanism of action of Radix Angelica sinensis (Oliv.) Diels and Radix Astragalus mongholicus Bunge ultrafiltration extract on radiation-induced myocardial fibrosis based on network pharmacology and experimental research EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES Chunzhen Ren WB Rat 1:5000 cardiac tissue

Aerobic exercise improves motor dysfunction in Parkinson's model mice via differential regulation of striatal medium spiny neuron Scientific Reports Yinhao Wang IF Mouse 1:500 brain tissue

Study on the mechanism of modified Gegen Qinlian decoction in regulating the intestinal flora-bile acid-TGR5 axis for the treatment of type 2 diabetes mellitus based on macro genome sequencing and targeted metabonomics integration PHYTOMEDICINE Rong Liu

Astragaloside IV mediates radiation-induced neuronal damage through activation of BDNF-TrkB signaling PHYTOMEDICINE Xin Liu WB Mouse,Rat 1:10000 PC12 cell,cortical neurons

Involvement of cGAS/STING Signaling in the Pathogenesis of Candida albicans Keratitis: Insights From Genetic and Pharmacological Approaches INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Shanmei Lyu WB Mouse corneal tissue

A novel oral TLR7 agonist orchestrates immune response and synergizes with PD-L1 blockade via type I IFN pathway in lung cancer INTERNATIONAL IMMUNOPHARMACOLOGY Xueying Zuo WB Mouse,Human Lewis lung carcinoma (LLC) cell-Xenograft A549 cell,LLC cell

The flavonoids from the fruits of Psoralea corylifolia and their potential in inhibiting metastasis of human non-small cell lung cancers BIOORGANIC CHEMISTRY Peixin Shi WB Human A549 cell

Chlorogenic Acid as a Potential Therapeutic Agent for Cholangiocarcinoma Pharmaceuticals Jiabao Liang WB Human RBE Cell

The Cellular Microbiome of Visceral Organs: An Inherent Inhabitant of Parenchymal Cells Microorganisms Xiaowei Sun WB Rat 1:5000 liver tissue, spleen tissue, kidney tissue, pancreas tissue, heart tissue, lung tissue, skeletal muscle tissue, brain tissue, intestinal tissue

IKBIP promotes tumor development via the akt signaling pathway in esophageal squamous cell carcinoma BMC CANCER Hu Jiannan WB Human KYSE-150 cell,KYSE-30 cell

miR-181d targets BCL2 to regulate HCT-8 cell apoptosis and parasite burden in response to Cryptosporidium parvum infection via the intrinsic apoptosis pathway VETERINARY PARASITOLOGY Juanfeng Li WB Human HCT-8 cell

Virus-Mimetic Extracellular-Vesicle Vaccine Boosts Systemic and Mucosal Immunity via Immune Recruitment ACS Nano Jingru Li WB Mouse 1:5000 extracellular vesicles

Mitochondria-targeted drug delivery system based on tetrahedral framework nucleic acids for bone regeneration under oxidative stress CHEMICAL ENGINEERING JOURNAL Yanjing Li WB Rat Primary periodontal stem cell(PDLSC)

SQSTM1 improves acute lung injury via inhibiting airway epithelium ferroptosis in a vitamin D receptor / autophagy-mediated manner FREE RADICAL BIOLOGY AND MEDICINE Youjing Yang IHC,IF Mouse,Human lung tissue HBE cell

DHA dietary intervention caused different hippocampal lipid and protein profile in ApoE-/- and C57BL/6J mice BIOMEDICINE & PHARMACOTHERAPY Lu Liu IHC Mouse 1:2000 brain tissue

N6-methyldeoxyadenosine modification difference contributes to homocysteine-induced mitochondrial perturbation in rat hippocampal primary neurons and PC12 cells BIOCHEMICAL PHARMACOLOGY Ling Zhang WB Rat 1:2000 PC12 cell

MiR-199a-3p regulates HCT-8 cell autophagy and apoptosis in response to Cryptosporidium parvum infection by targeting MTOR Communications Biology Wu Shanbo WB Human 1:5000 HCT-8 cell

AQP4- and Kir4.1-Mediated Müller Cell Oedema Is Involved in Retinal Injury Induced By Hypobaric Hypoxia MOLECULAR NEUROBIOLOGY Han Cong WB Mouse 1:10000 retinal tissue

Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway Frontiers in Pharmacology Jia Yanjun WB Rat PC12 cell

Exposure to Trimethyltin Chloride Induces Pyroptosis and Immune Dysfunction in Grass Carp CIK Cells by Activating the NF-κB Pathway Through Oxidative Stress ENVIRONMENTAL TOXICOLOGY Xiaotong Ni WB Fish 1:10000 CIK cell

The potential benefits of PGC-1α in treating Alzheimer's disease are dependent on the integrity of the LLKYL L3 motif: Effect of regulating mitochondrial axonal transportation EXPERIMENTAL GERONTOLOGY Hou-Zhen Shi WB Human brain tissue

M2 macrophages promote PD-L1 expression in triple-negative breast cancer via secreting CXCL1 PATHOLOGY RESEARCH AND PRACTICE Lifen Zhang WB Human MDA-MB-231 cell,SUM159 cell,THP-1 cell

The Global Landscapes of Lysine Crotonylation in Pseudorabies Virus Infection VIROLOGY Xiaoyong Chen WB Human HEK293T cell

H3K18 Lactylation Potentiates Immune Escape of Non-Small Cell Lung Cancer CANCER RESEARCH Zhang Cai WB Human,Mouse non-small cell lung cancer (NSCLC) tissue,LLC cell-xenograft A549 cell,NCI-H1299 cell,NCI-H1703 cell,NCI-H1944 cell,NCI-H1975 cell,NCI-H358 cell,PC-9 cell,BEAS-2B cell

Fluoride induces hepatointestinal damage and vitamin B2 mitigation by regulating IL-17A and Bifidobacterium in ileum Journal of Advanced Research Chen Liang WB Mouse Liver tissue,ileum tissue

FOSL1-mediated LINC01566 negatively regulates CD4+ T-cell activation in myasthenia gravis Journal of Neuroinflammation Li Lifang WB Human 1:10000 Jurkat cell

Hirudin delays the progression of diabetic kidney disease by inhibiting glomerular endothelial cell migration and abnormal angiogenesis BIOMEDICINE & PHARMACOTHERAPY Jiayi Zhang IHC Mouse kidney tissue

Duck CD40L as an adjuvant enhances systemic immune responses of avian flavivirus DNA vaccine npj Vaccines Huang Juan WB Duck 1:5000 Duck embryo fibroblasts (DEFs)

Rational Design of a Novel 6H-Benzo[c]chromen Series as Selective PI3Kα Inhibitors JOURNAL OF MEDICINAL CHEMISTRY Xue Shi WB Human MCF7 cell,T47D cell

DDX19A promotes gastric cancer cell proliferation and migration by activating the PI3K/AKT pathway Cancer Cell International Cheng Yu WB Human 1:10000 Gastric cancer (GC) tissue GES-1 cell,MGC-803 cell,BGC-823 cell,HGC-27 cell,AGS cell

CD5L up-regulates the TGF-β signaling pathway and promotes renal fibrosis LIFE SCIENCES Chao Chen IHC Mouse kidney tissue

Androgen deprivation exacerbates AD pathology by promoting the loss of microglia in an age-dependent manner LIFE SCIENCES Jiaxin Cao IHC Mouse 1:200 brain tissue

Plantaginis Semen Ameliorates Hyperuricemia Induced by Potassium Oxonate INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Tian Liu WB Rat 1:5000 kidney tissue

Mesoporous zinc-polyphenol nanozyme for attenuating renal ischemia–reperfusion injury Nanomedicine Zepeng Li WB Mouse,Human 1:5000 kidney tissue HK2 cell

Repurposing Anidulafungin for Alzheimer’s Disease via Fragment-Based Drug Discovery ACS Chemical Neuroscience Siqi Xie Dot Blot Human 1:5000 Aβ42 Fibril

TRIM103 activates the RLRs pathway to enhance antiviral response by targeting VP5 and VP7 DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY Beibei Qin WB Fish 1:2000 tenopharyngodon idella kidney (CIK) cell

The Neuroprotective and Anxiolytic Effects of Magnesium Sulfate on Retinal Dopaminergic Neurons in 6-OHDA-Induced Parkinsonian Rats: A Pilot Study Brain Sciences Leyi Huang WB Rat 1:2000 eye tissue

Kaempferol inhibited invasion and metastasis of gastric cancer cells by targeting AKT/GSK3β pathway based on network pharmacology and molecular docking JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH Xia-Qing Gao WB Human 1:10000 HGC27 cell,MKN45 cell

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