• Target：
• Mouse IgG(H+L)

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Goat

• Dilution：
• WB 1:5000-20000;IHC 1:20-100;ELISA 1:5000-20000

• Purification：
• The antibody was affinity-purified from goat antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 4 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• HRP* Goat Anti-Mouse IgG(H+L)

• Background：
• Immunoway secondary antibodies are available conjugated to enzyme, biotin or fluorophore for use in a variety of antibody-based applications including Western Blot, ImmunoHistoChemistry, ImmunoFluorescence, Flow Cytometry and ELISA. We offer high quality secondary antibodies from goat, rabbit and donkey sources for your each application. Serum adsorbed secondary antibodies are also available and are recommended for use with immunoglobulin-rich samples.

Cineole regulates Wnt/β-catenin pathway through Nrf2/keap1/ROS to inhibit bisphenol A-induced apoptosis, autophagy inhibition and immunosuppression of grass carp hepatocytes

Cineole regulates Wnt/β-catenin pathway through Nrf2/keap1/ROS to inhibit bisphenol A-induced apoptosis, autophagy inhibition and immunosuppression of grass carp hepatocytes

Hsa_circ_0001550 impairs decidualization by regulating the proliferation and apoptosis of endometrial stromal cells

Neuroprotection of boropinol-B in Cerebral Ischemia-reperfusion Injury by Inhibiting Inflammation and Apoptosis

New STAT3 inhibitor through biotransformation of celastrol by Streptomyces olivaceus CICC 23628

FOXG1 Contributes Adult Hippocampal Neurogenesis in Mice

Combined negative effects of microplastics and plasticizer DEHP: The increased release of Nets delays wound healing in mice SCIENCE OF THE TOTAL ENVIRONMENT Xu Shi, Tong Xu, Wei Cui, Xue Qi, Shiwen Xu WB Mouse skin tissue neutrophils,fibroblasts

Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation Cells Ying Zhou, Jia-Jie Yang, Yuan Cheng, Ge-Xuan Feng, Rong-Hui Yang, Yuan Yuan, Li-Yong Wang, Miao Wang, Lu Kong WB Rat, Human adipose, liver 7701 cell, AD-MSCs, HEK293T cell, HepG2 cell, MHCC97-H cell

Breast Cancer Vaccine Containing a Novel Toll-like Receptor 7 Agonist and an Aluminum Adjuvant Exerts Antitumor Effects INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Shuquan Zhang, Yu Liu, Ji Zhou, Jiaxin Wang, Guangyi Jin, Xiaodong Wang ELISA Mouse serum

Paiteling induces apoptosis of cervical cancer cells by down-regulation of the E6/E7-Pi3k/Akt pathway: A network pharmacology JOURNAL OF ETHNOPHARMACOLOGY Yunhua Liu, Pengfei Zheng, Tingting Jiao, Mengmeng Zhang, Yingjie Wu, Xinjiang Zhang, Shuyue Wang, Zongjiang Zhao WB Human HeLa cell, Ect1/E6E7 cell

Selenium mitigates the inhibitory effect of TBBPA on NETs release by regulating ROS/MAPK pathways-induced carp neutrophil apoptosis and necroptosis FISH & SHELLFISH IMMUNOLOGY Duqiang Gong, Kexin Sun, Kexin Yin, Xu Wang WB Fish neutrophil

Protective effect of Cistanche deserticola on gentamicin-induced nephrotoxicity in rats Chinese Herbal Medicines Rui-bin Bai, Jing-min Fan, Yan-ping Wang, Yan Wang, Xue Li, Fang-di Hu WB Rat kidney

STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway WB Mouse,Human lung tissues/human bronchial epithelial HBE cells

Assessment of Fasudil on Contrast-Associated Acute Kidney Injury Using Multiparametric Renal MRI WB Rat 1:10000 kidney tissues/

Shen Qi Wan Ameliorates Learning and Memory Impairment Induced by STZ in AD Rats through PI3K/AKT Pathway WB Mouse 1:5000 hippocampus tissue/

Parkin, as a Regulator, Participates in Arsenic Trioxide-Triggered Mitophagy in HeLa Cells WB Human 1:5000 /HeLa cells

Proteomic Study on the Reproductive Toxicity of Tripterygium Glycosides in Rats WB Rat testis tissue /

Design, Synthesis, and Apoptosis-Promoting Effect Evaluation of Rhopaladins’ Analog 4-Arylidene-5-Oxopyrrolidine Derivatives WB Human 1:5000 /HepG2 cell, 7402 cell

Neuronal STAT3/HIF-1α/PTRF axis-mediated bioenergetic disturbance exacerbates cerebral ischemia-reperfusion injury via PLA2G4A. Theranostics2022; 12(7): 3196–3216. Mouse 1:10000 HT22 cell

Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway. Stem Cell Research & Therapy2022 Dec;13(1):1-15. Human,Mouse 1:3000 liver tissue hUC-MSC

Chitosan Oligosaccharides Alleviate H2O2-stimulated Granulosa Cell Damage via HIF-1α Signaling Pathway. Oxidative Medicine and Cellular LongevityOxid Med Cell Longev. 2022;2022:4247042. Human 1 : 3000 KGN cell

The CK1δ/ϵ-Tip60 Axis Enhances Wnt/β-Catenin Signaling via Regulating β-Catenin Acetylation in Colon Cancer. Frontiers in Oncology2022 Apr;0:1567. Human HEK293T cell

mTORC1 is a key regulator that mediates OGD‑ and TGFβ1‑induced myofibroblast transformation and chondroitin‑4‑sulfate expression in cardiac fibroblasts. Experimental and Therapeutic Medicine2022 Jun;23(6):1-13. Rat cardiac fibroblasts (CFs)

mTORC1 is a key regulator that mediates OGD‑ and TGFβ1‑induced myofibroblast transformation and chondroitin‑4‑sulfate expression in cardiac fibroblasts. Experimental and Therapeutic Medicine2022 Jun;23(6):1-13. Rat cardiac fibroblasts (CFs)

Cineole alleviates the BPA-inhibited NETs formation by regulating the p38 pathway-mediated programmed cell death. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY2022 Jun;237:113558. Chicken 1:8000 neutrophil extracellular traps (NETs)

Chronic exposure of bisphenol-A impairs cognitive function and disrupts hippocampal insulin signaling pathway in male mice. TOXICOLOGY2022 Apr;472:153192. Mouse 1:10000 hippocampal tissues

Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis. ARTHRITIS RESEARCH & THERAPY2022 Dec;24(1):1-14. Human cartilage tissue chondrocytes

Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms Free Radical Bio Med. 2022 Mar;182:59. WB Mouse 1:10000 cerebral cortical

STAT6/VDR Axis Mitigates Lung Inflammatory Injury by Promoting Nrf2 Signaling Pathway Oxid Med Cell Longev. 2022;2022:2485250. WB,IF,IHC Mouse,Human lung

Lysine decrotonylation of glutathione peroxidase at lysine 220 site increases glutathione peroxidase activity to resist cold stress in chrysanthemum Ecotox Environ Safe. 2022 Mar;232:113295. WB Chrysanthemum 1:10000 leaves

HIF-1α Negatively Regulates Irisin Expression Which Involves in Muscle Atrophy Induced by Hypoxia Int J Mol Sci. 2022 Jan;23(2):887. WB Mouse 1:10000 Gastrocnemius muscle

Eurotium cristatum, a Probiotic Fungus from Fuzhuan Brick Tea, and Its Polysaccharides Ameliorated DSS-Induced Ulcerative Colitis in Mice by Modulating the Gut Microbiota J Agr Food Chem. 2022;70(9):2957–2967. WB Mouse colon tissues

Exosomal miR-543 Inhibits the Proliferation of Ovarian Cancer by Targeting IGF2 J Immunol Res. 2022;2022:2003739. WB Human

DJ-1 upregulates the Nrf2/GPX4 signal pathway to inhibit trophoblast ferroptosis in the pathogenesis of preeclampsia Sci Rep-Uk. 2022 Feb;12(1):1-16. WB,IHC Human 1:1000 Placenta

Positive effects of selenium supplementation on selenoprotein S expression and cytokine status in a murine model of acute liver injury J Trace Elem Med Bio. 2022 May;71:126927. WB Mouse liver

Angiopoietin-like protein 4 promotes hyperlipidemia-induced renal injury by down-regulating the expression of ACTN4 Biochem Bioph Res Co. 2022 Mar;595:69. IHC Mouse Renal

The Hippo signaling component LATS2 enhances innate immunity to inhibit HIV-1 infection through PQBP1-cGAS pathway. CELL DEATH AND DIFFERENTIATION Cell Death Differ. 2021 Aug;:1-14 WB Human THP1 cell

Atractylenolide-I covalently binds to CYP11B2, selectively inhibits aldosterone synthesis, and improves hyperaldosteronism. Acta Pharmaceutica Sinica B Acta Pharm Sin B. 2021 Sep;: WB Human 1:5000 NCI-H295R cell

Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells. Cell Death & Disease Cell Death Dis. 2021 May;12(5):1-13 IHC Human Skin

TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways. Cell Death & Disease Cell Death Dis. 2020 Jan;11(1):1-15 WB Rat heart

Upregulation of autophagy in M2 macrophage by vitamin D alleviates crystalline silica-induced pulmonary inflammatory damage. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Ecotox Environ Safe. 2021 Dec;225:112730 IF Human THP-1 cell

Autophagy was activated against the damages of placentas caused by nano-copper oral exposure. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Ecotox Environ Safe. 2021 Sep;220:112364 WB Rat 1：1000000 Placentas

KDF1, a Novel Tumor Suppressor in Clear Cell Renal Cell Carcinoma. Frontiers in Oncology Front Oncol. 2021; 11: 686678 WB Human Non-tumor renal tissue,ccRCC tumor tissue

Pregnenolone Overproduction in Yarrowia lipolytica by Integrative Components Pairing of the Cytochrome P450scc System. ACS Synthetic Biology 2019 Oct 17 WB Y. lipolytica 1:10000

Matrix Remodeling Associated 7 Deficiency Alleviates Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Frontiers in Immunology 2018 Apr 18 WB Mouse liver tissues

Sucralose enhances the susceptibility to dextran sulfate sodium (DSS) induced colitis in mice with changes in gut microbiota. Food & Function Food Funct. 2021 Oct;12(19):9380-9390 WB Mouse Colonic tissue

Sesamin protects against DSS-induced colitis in mice by inhibiting NF-κB and MAPK signaling pathways. Food & Function Food Funct. 2021 Mar;12(4):1688-1694 WB Mouse Colonic tissue

Bixin Protects Against Kidney Interstitial Fibrosis Through Promoting STAT6 Degradation. Frontiers in Cell and Developmental Biology Front Cell Dev Biol. 2020; 8: 576988 IF Human HK2 cell

Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY J Enzym Inhib Med Ch. 2022;37(1):236-251 WB Human HCT-116 cell

Dioscin prevents DSS-induced colitis in mice with enhancing intestinal barrier function and reducing colon inflammation. INTERNATIONAL IMMUNOPHARMACOLOGY Int Immunopharmacol. 2021 Oct;99:108015 WB Mouse Colonic tissue

α-Arbutin Protects Against Parkinson’s Disease-Associated Mitochondrial Dysfunction In Vitro and In Vivo. NEUROMOLECULAR MEDICINE Neuromol Med. 2020 Mar;22(1):56-67 WB Human SH-SY5Y cell

Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6. Journal of Immunology Research J Immunol Res. 2021;2021:8875450 WB Human SKOV3 cell

A novel halogenated adenosine analog 5’-BrDA displays potent toxicity against colon cancer cells in vivo and in vitro. TOXICOLOGY AND APPLIED PHARMACOLOGY Toxicol Appl Pharm. 2022 Feb;436:115857 WB Human 1 : 5000 HT-29 cell

Bixin Confers Prevention against Ureteral Obstruction-Caused Renal Interstitial Fibrosis through Activation of the Nuclear Factor Erythroid-2-Related Factor2 Pathway in Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY J Agr Food Chem. 2020;68(31):8321–8329 IF Human HK2 cell

LncRNA PVT1 regulates VEGFC through inhibiting miR‐128 in bladder cancer cells. JOURNAL OF CELLULAR PHYSIOLOGY 2018 Aug 04 WB Human 1:1000 UM-UC-3 cell

lncRNA LA16c‑313D11.11 modulates the development of endometrial cancer by binding to and inhibiting microRNA‑205‑5p function and indirectly increasing PTEN activity. INTERNATIONAL JOURNAL OF ONCOLOGY Int J Oncol. 2020 Jul;57(1):355-363 WB Human 1:5000 HEC-1A cell, Ishikawa cell

The Abilities of Salidroside on Ameliorating Inflammation, Skewing the Imbalanced Nucleotide Oligomerization Domain-Like Receptor Family Pyrin Domain Containing 3/Autophagy, and Maintaining Intestinal Barrier Are Profitable in Colitis. Frontiers in Pharmacology 2019 Dec 02 WB,IHC Mouse colon

Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA‐30a in breast cancer. MOLECULAR CARCINOGENESIS Mol Carcinogen. 2020 Aug;59(8):908-922 WB Human MCF-7 cell,MDA-MB-231 cell

The effect of miR-223 on cellular behaviour in non-5q myelodysplastic syndromes through targeting RPS14. PATHOLOGY Pathology. 2020 Aug;52:552 WB Human SKM-1 cell

Dipotassium glycyrrhizinate relieves leptospira-induced nephritis in vitro and in vivo. MICROBIAL PATHOGENESIS Microb Pathogenesis. 2021 Mar;152:104770 WB Mouse 1:20000 TCMK-1 cell

Liraglutide protects pancreatic β cells from endoplasmic reticulum stress by upregulating MANF to promote autophagy turnover. LIFE SCIENCES Life Sci. 2020 Jul;252:117648 WB Rat MIN6 cell

Noncoding RNA 886 alleviates tumor cellular immunological rejection in host C57BL/C mice. Cancer Medicine Cancer Med-Us. 2020 Jul;9(14):5258-5271 WB Human 1:10000 1E8 cell

TRPS1 knockdown inhibits angiogenic vascular mimicry in human triple negative breast cancer cells. Clinical & Translational Oncology Clin Transl Oncol. 2022 Jan;24(1):145-153 WB Human MDA-MB-231 cells， sh-NC cells, TRPS1low-siRNA3 cell

Cucurbitacin B inhibits the migration and invasion of breast cancer cells by altering the biomechanical properties of cells. PHYTOTHERAPY RESEARCH Phytother Res. 2019 Mar;33(3):618-630 WB Mouse 1:500 SKBR-3 cell-xenograft，lung tissue

Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy Diabet Metab Synd Ob. 2019; 12: 1811–1820 WB,IF Rat 1:100,1:5000 kidney podocytes

Ponicidin inhibits pro-inflammatory cytokine TNF-α-induced epithelial–mesenchymal transition and metastasis of colorectal cancer cells via suppressing the AKT/GSK-3β/Snail pathway. INFLAMMOPHARMACOLOGY Inflammopharmacology. 2019 Jun;27(3):627-638 WB Human 1:10000 HCT116 cell

Blocking MAPK/ERK pathway sensitizes hepatocellular carcinoma cells to temozolomide via downregulating MGMT expression.. Annals of Translational Medicine Ann Transl Med. 2020 Oct; 8(20): 1305 WB Human 1 : 10000 HepG2 cell

Garlic flavonoids alleviate H2O2 induced oxidative damage in L02 cells and induced apoptosis in HepG2 cells by Bcl‐2/Caspase pathway. JOURNAL OF FOOD SCIENCE J Food Sci. 2021 Feb;86(2):366-375 WB Human HepG2 cell

Long non-coding RNA ROR promotes radioresistance in hepatocelluar carcinoma cells by acting as a ceRNA for microRNA-145 to regulate RAD18 expression. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2018 Mar 17 WB Human HepG2 cell,SMMC-7721 cell

Effects of HIF-1α on Spermatogenesis of Varicocele Rats by Regulating VEGF/PI3K/Akt Signaling Pathway. Reproductive Sciences Reprod Sci. 2021 Apr;28(4):1161-1174 WB Rat 1:10000 Testicular tissue

Use of four genes in exosomes as biomarkers for the identification of lung adenocarcinoma and lung squamous cell carcinoma. Oncology Letters Oncol Lett. 2021 Apr;21(4):1-1 WB Human 1:10000 Blood

The expression and prognostic role of EBP1 and relationship with AR in HER2+ breast cancer. VIRCHOWS ARCHIV 2020 Aug;477(2):279-289 WB Human 1:2000 breast cancer (BC) tissue

Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction. BIOSCIENCE REPORTS Bioscience Rep. 2018 Dec;38(6):BSR20180519 WB Rat heart tissues H9c2 cell

Autophagy enhanced antitumor effect in K562 and K562/ADM cells using realgar transforming solution. BIOMEDICINE & PHARMACOTHERAPY 2017 Dec 27 IF Human K562 cell

Effects and Mechanism of Plasma-Activated Medium on Angiogenesis of Vascular Endothelial Cells. Applied Sciences-Basel 2021 Jan;11(20):9603 WB Human 1:5000 HUVECs

Relationship between PI3K/mTOR/RhoA pathway-regulated cytoskeletal rearrangements and phagocytic capacity of macrophages. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH Braz J Med Biol Res. 2020 Jun;53: WB Mouse 1:5000 RAW264.7 cells

Targeting at cancer energy metabolism and lipid droplet formation as new treatment strategies for epigallocatechin-3-gallate (EGCG) in colorectal cancer cells. Journal of Functional Foods J Funct Foods. 2021 Aug;83:104570 IF Human 1:500 HCT116 cell

The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection. Stem Cell Research & Therapy Stem Cell Res Ther. 2021 Dec;12(1):1-12 WB Pig Liver

Bixin protects against particle-induced long-term lung injury in an NRF2-dependent manner. Toxicology Research 2018 Mar 05 WB Human THP-1 cell

Therapeutic potential of bixin in PM2.5 particles-induced lung injury in an Nrf2-dependent manner. FREE RADICAL BIOLOGY AND MEDICINE Free Radical Bio Med. 2018 Oct;126:166 IF Human BEAS-2B cell

MiR-19a suppress apoptosis of myocardial cells in rats with myocardial ischemia/reperfusion through PTEN/Akt/P-Akt signaling pathway. European Review for Medical and Pharmacological Sciences Eur Rev Med Pharmaco. 2020 Mar;24(6):3322-3330 WB Rat H9c2 cell

Vitamin D protects against particles‐caused lung injury through induction of autophagy in an Nrf2‐dependent manner. ENVIRONMENTAL TOXICOLOGY Environ Toxicol. 2019 May;34(5):594-609 IF Human THP-1 cell,BEAS-2B cell

MiR-335-5p inhibits proliferation of Huh-7 liver cancer cells via targeting the Oct4/Akt pathway.. European Review for Medical and Pharmacological Sciences Eur Rev Med Pharmaco. 2021 Feb;25(4):1853-1860 WB Human Huh7 cell

LncRNA ROR promotes proliferation of endometrial cancer cells via regulating Notch1 pathway.. European Review for Medical and Pharmacological Sciences Eur Rev Med Pharmaco. 2020 Jun;24(11):5970-5978 WB Human HEC-1A cell

Curcumin is a Potential Adjuvant to Alleviates Diabetic Retinal Injury via Reducing Oxidative Stress and Maintaining Nrf2 Pathway Homeostasis. Frontiers in Pharmacology Front Pharmacol. 2021 Dec;0:3696 WB Rat 1:5000 Retinal tissue

Modulations of Keap1-Nrf2 signaling axis by TIIA ameliorated the oxidative stress-induced myocardial apoptosis. FREE RADICAL BIOLOGY AND MEDICINE Free Radical Bio Med. 2018 Feb;115:191 IF Mouse Myocardial

Neuroprotective effect of Hongjing I granules on erectile dysfunction in a rat model of bilateral cavernous nerve injury. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2020 Oct;130:110405 WB Rat Penis

The Hippo signaling component LATS2 enhances innate immunity to inhibit HIV-1 infection through PQBP1-cGAS pathway. CELL DEATH AND DIFFERENTIATION Cell Death Differ. 2021 Aug;:1-14 IF Human HeLa cell， THP1 cell

Cardiac Glycoside Compound Isolated from Helleborus thibetanus Franch Displays Potent Toxicity against HeLa Cervical Carcinoma Cells through ROS-Independent Autophagy. CHEMICAL RESEARCH IN TOXICOLOGY Chem Res Toxicol. 2019;32(12):2479–2487 WB Human HeLa cell

hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR‐139‐3p/CCL5 axis. CANCER SCIENCE Cancer Sci. 2022 Feb; 113(2): 634–647 WB Human HCC cell

Chronic CagA‐positive Helicobacter pylori infection with MNNG stimulation synergistically induces mesenchymal and cancer stem cell‐like properties in gastric mucosal epithelial cells. JOURNAL OF CELLULAR BIOCHEMISTRY J Cell Biochem. 2019 Oct;120(10):17635-17649 WB Human GES-1 cell

Mesenchymal stem cell-derived extracellular vesicles promote apoptosis in RSC96 Schwann cells through the activation of the ERK pathway. International Journal of Clinical and Experimental Pathology Int J Clin Exp Patho. 2018; 11(11): 5157–5170 WB Rat RSC96 cell

Pink1/PARK2/mROS-Dependent Mitophagy Initiates the Sensitization of Cancer Cells to Radiation. Oxidative Medicine and Cellular Longevity Oxid Med Cell Longev. 2021;2021:5595652 WB Human HeLa cell， MCF-7 cell

ROS Induced by KillerRed Targeting Mitochondria (mtKR) Enhances Apoptosis Caused by Radiation via Cyt c/Caspase-3 Pathway. Oxidative Medicine and Cellular Longevity Oxid Med Cell Longev. 2019;2019:4528616 WB Human 1 : 1000 HeLa cell

Realgar transforming solution-induced differentiation of NB4 cell by the degradation of PML/RARα partially through the ubiquitin–proteasome pathway. ARCHIVES OF PHARMACAL RESEARCH Arch Pharm Res. 2019 Aug;42(8):684-694 WB Human 1: 5000 NB4 cell

CXCL2 benefits acute myeloid leukemia cells in hypoxia. International Journal of Laboratory Hematology Int J Lab Hematol. 2021 Oct;43(5):1085-1092 WB Human 1:5000 THP-1cell， HL-60 cell

Pharmaceutic application of vitamin D3 on particle-induced fibrotic effects through induction of Nrf2 signals. Toxicology Research 2020 Apr 24 IF Human BEAS-2B cell,HFLIII cell

Contributions of Nrf2 to Puerarin Prevention of Cardiac Hypertrophy and its Metabolic Enzymes Expression in Rats. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS J Pharmacol Exp Ther. 2018 Sep;366(3):458-469 WB Rat ventricular tissue cardiomyocytes

Contributions of Nrf2 to Puerarin Prevention of Cardiac Hypertrophy and its Metabolic Enzymes Expression in Rats. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS J Pharmacol Exp Ther. 2018 Sep;366(3):458-469 WB Rat ventricular tissue cardiomyocytes

The preparation of a cold-water soluble polysaccharide from Grifola frondosa and its inhibitory effects on MKN-45 cells. GLYCOCONJUGATE JOURNAL 2020 Jun 15 WB Human MKN-45 cell

Intracellular ion and protein nanoparticle-induced osmotic pressure modify astrocyte swelling and brain edema in response to glutamate stimuli. Redox Biology Redox Biol. 2019 Feb;21:101112 WB Rat Astrocyte

Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2019 Apr;112:108669 WB Mouse Primary murine lung fibroblasts (PMLFs)

HIV p17 enhances T cell proliferation by suppressing autophagy through the p17‐OLA1‐GSK3β axis under nutrient starvation. JOURNAL OF MEDICAL VIROLOGY J Med Virol. 2021 Jun;93(6):3607-3620 WB Human Jurkat cell

Protective Effect of Adipose-Derived Mesenchymal Stem Cell Secretome against Hepatocyte Apoptosis Induced by Liver Ischemia-Reperfusion with Partial Hepatectomy Injury. Stem Cells International Stem Cells Int. 2021;2021:9969372 WB Pig Liver

Treadmill Exercise Attenuates Cerebral Ischemia–Reperfusion Injury by Promoting Activation of M2 Microglia via Upregulation of Interleukin-4. Frontiers in Cardiovascular Medicine Front Cardiovasc Med. 2021 Oct;0:1282 WB Rat 1:10000 Penumbra

Salidroside Improves Chronic Stress Induced Depressive Symptoms Through Microglial Activation Suppression. Frontiers in Pharmacology Front Pharmacol. 2021 Jun;0:1442 IF Mouse Brain Primary microglia cells

Down-regulation of RCC1 sensitizes immunotherapy by up-regulating PD-L1 via p27kip1/CDK4 axis in non-small cell lung cancer. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE J Cell Mol Med. 2021 Apr;25(8):4136-4147 WB Human 1:10000 A549 cell，H1299 cell

Ginsenoside Rg1 Alleviates Podocyte Injury Induced by Hyperlipidemia via Targeting the mTOR/NF-κB/NLRP3 Axis. Evidence-based Complementary and Alternative Medicine Evid-Based Compl Alt. 2020;2020:2735714 WB Rat 1 : 5000 Renal tubule，Kidney Podocyte

Radix Angelica Sinensis and Radix Hedysari Ultrafiltration Extract Protects against X-Irradiation-Induced Cardiac Fibrosis in Rats. Evidence-based Complementary and Alternative Medicine Evid-Based Compl Alt. 2020;2020:4675851 WB Rat cardiac fibroblasts

Inhibition of Uncoupling Protein 2 Enhances the Radiosensitivity of Cervical Cancer Cells by Promoting the Production of Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity Oxid Med Cell Longev. 2020;2020:5135893 WB Human 1 : 10000 HeLa cell

Kaempferol potentiates the sensitivity of pancreatic cancer cells to erlotinib via inhibition of the PI3K/AKT signaling pathway and epidermal growth factor receptor. INFLAMMOPHARMACOLOGY Inflammopharmacology. 2021 Oct;29(5):1587-1601 WB Human PANC-1，BxPC-3

Rapamycin inhibits proliferation and apoptosis of retinoblastoma cells through PI3K/AKT signaling pathway. Oncology Letters Oncol Lett. 2020 Apr;19(4):2950-2956 WB Human Y79 cell

miR-128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF-C upregulation. Oncology Letters 2015 Sep 09 WB Human 1:1000 SV-HUC-1 cell,T24 cell, 5637 cell

Inhibitory effects of alkaline extract from the pericarp of Citrus reticulata Blanco on collagen behavior in bleomycin-induced pulmonary fibrosis. JOURNAL OF ETHNOPHARMACOLOGY J Ethnopharmacol. 2021 Apr;269:113761 IHC,WB Mouse 1:1000 Lung

Lysine crotonylation of DgTIL1 at K72 modulates cold tolerance by enhancing DgnsLTP stability in chrysanthemum. PLANT BIOTECHNOLOGY JOURNAL Plant Biotechnol J. 2021 Jun; 19(6): 1125–1140 WB Chrysanthemum，Tobacco 1:10000 Leaves

Function of Chick Subcutaneous Adipose Tissue During the Embryonic and Posthatch Period. Frontiers in Physiology Front Physiol. 2021; 12: 684426 WB Chicken Adipose，liver

Effect of metformin on apoptosis, cell cycle arrest migration and invasion of A498 cells. Molecular Medicine Reports 2014 Mar 31 WB Human A498 cell

Effects of DHA dietary intervention on hepatic lipid metabolism in apolipoprotein E-deficient and C57BL/6J wild-type mice. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2021 Dec;144:112329 IHC Mouse Liver

The tissue expression level of BPI gene in piglets from newborn to weaning and its relationship with Gram-negative bacterial infection. Journal of Integrative Agriculture J Integr Agr. 2020 Dec;19:3065 WB Pig 1:5000 IPEC-J2 cells

Zeng, Xiaozhu, et al. "Down‐regulation of RCC1 sensitizes immunotherapy by up‐regulating PD‐L1 via p27kip1/CDK4 axis in non‐small cell lung cancer." Journal of cellular and molecular medicine 25.8 (2021): 4136-4147.

Zhang, Yanyan, et al. "Salidroside Ameliorates Vascular Endothelial Cell Senescence through Downregulation of KLF4." Journal of Biosciences and Medicines 9.2 (2021): 21-32.

Meng, Fanwei, et al. "Anti-inflammatory effects of DhHP-6 in LPS-induced RAW264. 7 macrophages and carrageenan-induced air pouch model in rat." (2021).

Xin, Weijuan, et al. "lncRNA LA16c‑313D11. 11 modulates the development of endometrial cancer by binding to and inhibiting microRNA‑205‑5p function and indirectly increasing PTEN activity." International journal of oncology 57.1 (2020): 355-363.

王万林, et al. "艾纳香油对 NF-κB 及 Nrf2/HO-1 信号通路的作用研究." 畜牧兽医学报 52.4 (2021): 976-986.

The protective capability of Hedyotis diffusa Willd on lupus nephritis by attenuating the IL-17 expression in MRL/lpr mice Frontiers in Immunology Li Xu IHC,IF Mouse

Black mulberry (Morus nigra) fruit extract alleviated AD-Like symptoms induced by toxic Aβ protein in transgenic Caenorhabditis elegans via insulin DAF-16 signaling pathway FOOD RESEARCH INTERNATIONAL Yan Liu WB Caenorhabditis elegans

Flavonoid Group of Smilax glabra Roxb. Regulates the Anti-Tumor Immune Response Through the STAT3/HIF-1 Signaling Pathway Frontiers in Pharmacology Qiyang Shou WB Mouse

Caffeine Decreases Hepcidin Expression to Alleviate Aberrant Iron Metabolism under Inflammation by Regulating the IL-6/STAT3 Pathway Life-Basel Zhong-Da Li WB Mouse

Gluconeogenesis Alteration and p53-SIRT6-Fox01 Signaling Adaptive Regulation in Sheep from Different Grazing Periods Computational and Mathematical Methods in Medicine Jinling Cao WB Sheep

Histatin-1 alleviates high-glucose injury to skin keratinocytes through MAPK signaling pathway Journal of Cosmetic Dermatology Xuanfen Zhang MD WB Human

LncRNA GAS6-AS1 facilitates tumorigenesis and metastasis of colorectal cancer by regulating TRIM14 through miR-370-3p/miR-1296-5p and FUS Journal of Translational Medicine Jie Wu WB Human

Protective effect of adipose-derived stromal cell-secretome attenuate autophagy induced by liver ischemia–reperfusion and partial hepatectomy Stem Cell Research & Therapy Hongbin Wang WB Pig

Network Pharmacology, Molecular Docking, and Experimental Validation to Unveil the Molecular Targets and Mechanisms of Compound Fuling Granule to Treat Ovarian Cancer Oxidative Medicine and Cellular Longevity Fangfang Tao WB Human

Vitamin D protects silica particles induced lung injury by promoting macrophage polarization in a KLF4-STAT6 manner JOURNAL OF NUTRITIONAL BIOCHEMISTRY Shasha Tao WB Human,Mouse

The anti-inflammatory effects of Hedyotis diffusa Willd on SLE with STAT3 as a key target JOURNAL OF ETHNOPHARMACOLOGY Li Xu WB Mouse

ROS-mediated PPAR/RXR inhibition contributes to acetochlor-induced apoptosis and autophagy in Ctenopharyngodon idella hepatic cells FISH & SHELLFISH IMMUNOLOGY Yuhong Yang WB Fish

Electroacupuncture of Baihui and Shenting ameliorates cognitive deficits via Pten/Akt pathway in a rat cerebral ischemia injury model. Frontiers in Neurology Xiaodong Feng WB Rat

Electroacupuncture of Baihui and Shenting ameliorates cognitive deficits via Pten/Akt pathway in a rat cerebral ischemia injury model. Frontiers in Neurology Xiaodong Feng WB Rat

Electroacupuncture of Baihui and Shenting ameliorates cognitive deficits via Pten/Akt pathway in a rat cerebral ischemia injury model. Frontiers in Neurology Xiaodong Feng WB Rat

Anti-Inflammation and Anti-Pyroptosis Activities of Mangiferin via Suppressing NF-κB/NLRP3/GSDMD Signaling Cascades INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Shidong Zhang WB Mouse

Mitochondrial-Targeting Vitamin B3 Ameliorates the Phenotypes of Parkinson's Disease In Vitro and In Vivo by Restoring Mitochondrial Function Advanced Therapeutics Hua Bai WB Human

Barrigenol-like triterpenoid saponins from the husks of Xanthoceras sorbifolia bunge and their anti-inflammatory activity by inhibiting COX-2 and iNOS expression PHYTOCHEMISTRY Dali Meng WB Mouse

Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage JOURNAL OF BONE AND MINERAL METABOLISM Jian Sun WB Human

Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes

Highly Stable Fibronectin-mimetic-peptide-based Supramolecular Hydrogel to Accelerate Corneal Wound Healing Acta Biomaterialia Jiaqing Wang WB Human human corneal epithelial cells (HCECs)

CHIR99021 Maintenance of the Cell Stemness by Regulating Cellular Iron Metabolism Antioxidants Yan-Zhong Chang WB Mouse Neuro-2a cell

Ameliorative effects of different doses of selenium against fluoride-triggered apoptosis and oxidative stress-mediated renal injury in rats through the activation of Nrf2/HO-1/NQO1 signaling pathway FOOD AND CHEMICAL TOXICOLOGY Jinming Wang IHC,IF Rat kidney

Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma Epigenetics Xianhe Xie WB Human Head and neck squamous cell carcinoma (HNSCC)

ROS mediated pyroptosis-M1 polarization crosstalk participates in inflammation of chicken liver induced by bisphenol A and selenium deficiency ENVIRONMENTAL POLLUTION Shiwen Xu WB Chicken liver Chicken liver cancer (LMH) cell ,chicken macrophages (HD11)cell

TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo ARTHRITIS RESEARCH & THERAPY Lin Huang IHC Rat disc samples

Clinopodium chinense Kuntze ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by reducing systematic inflammation and regulating metabolism JOURNAL OF ETHNOPHARMACOLOGY Dali Meng WB Mouse colon RAW264.7 cell

Euphohelides A–C, ent-Abietane-Type Norditerpene Lactones from Euphorbia helioscopia and Their Anti-Inflammatory Activities JOURNAL OF NATURAL PRODUCTS Kun Gao WB Mouse RAW264.7 cell

Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice BIOLOGICAL TRACE ELEMENT RESEARCH Sun, Zilong WB Mouse liver tissues

Effectiveness of fractional carbon dioxide laser combined with botulinum toxin type A in a rabbit ear model with the underlying mechanism Journal of Cosmetic Dermatology Huicai Wen IHC,WB Rabbit scar tissues

Ameliorating role of Tetrastigma hemsleyanum polysaccharides in antibiotic-induced intestinal mucosal barrier dysfunction in mice based on microbiome and metabolome analyses INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Zhishan Ding IHC Mouse colon tissue

The pathological significance and potential mechanism of ARHGEF6 in lung adenocarcinoma COMPUTERS IN BIOLOGY AND MEDICINE Shikang Li WB Human A549 cell

Costunolide covalently targets and inhibits CaMKII phosphorylation to reduce ischemia-associated brain damage PHYTOMEDICINE Min Jiang WB Rat cerebrovascular tissue

The novel polyfluoroalkyl benzenesulfonate OBS exposure induces cell cycle arrest and senescence of rat pituitary cell GH3 via the p53/p21/RB pathway TOXICOLOGY Qiyu Wang WB Rat GH3 cell

Glucose-driven transformable complex eliminates biofilm and alleviates inflamm-aging for diabetic periodontitis therapy. Bin Liu WB Mouse 1:5000 RAW264.7 ​cell

Lysine malonylation of DgnsLIPID TRANSFER PROTEIN1 at the K81 site improves cold resistance in chrysanthemum. Qinglin Liu WB Dendranthema grandiflorum chrysanthemum leave

Guiqi Baizhu prescription ameliorates cytarabine-induced intestinal mucositis by targeting JAK2 to inhibit M1 macrophage polarization. Yong-qi Liu WB Mouse 1:5000 ileal tissue M1 macrophage (M1)

Astragaloside IV ameliorates radiation-induced nerve cell damage by activating the BDNF/TrkB signaling pathway. Baoping Shao WB Mouse 1:10000 brain tissue PC12 cell,primary cortical neurons

Echinacea Polyphenols Inhibit NLRP3-Dependent Pyroptosis, Apoptosis, and Necroptosis via Suppressing NO Production during Lipopolysaccharide-Induced Acute Lung Injury. Xiaoqiang Liu WB Mouse 1:5000 lung tissue A549 cell

Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury. Baofei Sun WB Mouse 1:10000 BV2 cell

Dexmedetomidine attenuates sleep deprivation-induced inhibition of hippocampal neurogenesis via VEGF-VEGFR2 signaling and inhibits neuroinflammation. Qian Zhai WB Mouse 1:10000 Hippocampal tissue

Acute myeloid leukemia (AML)-derived mesenchymal stem cells induce chemoresistance and epithelial–mesenchymal transition-like program in AML through IL-6/JAK2/STAT3 signaling. Li Zhao WB Human 1:5000 K562 cell,HL60 cell

Intestinal microbiota regulates colonic inflammation in fluorosis mice by TLR/NF-κB pathway through short-chain fatty acids. Zilong Sun WB Mouse 1:10000 colon tissue

Benzene, 1,2,4-trimethoxy-5-(2-methyl-1-propen-1-yl) Attenuates D-galactose /AlCl3-induced Cognitive Impairment by Inhibiting Inflammation, Apoptosis, and Improving Expression of Memory-Related Proteins. Shengjun Mao WB Mouse 1:5000 hippocampal tissue

Co-Immunization with DNA Vaccines Expressing SABP1 and SAG1 Proteins Effectively Enhanced Mice Resistance to Toxoplasma gondii Acute Infection. Na Yang ELISA Mouse serum

Dangshen Huangjiu exerts prevention of gastric mucosal injury and inhibits Akt/NF-κB signaling. Fangdi Hu WB Rat,Human gastric mucosal tissues GES-1 cell

Retinoid X receptor agonists alleviate fibroblast activation and post-infarction cardiac remodeling via inhibition of TGF-β1/Smad pathway. Da-jun Chai WB Rat heart

Overexpression of POLA2 in hepatocellular carcinoma is involved in immune infiltration and predicts a poor prognosis. Xuequan Wang WB Human Hepatocellular carcinoma (HCC) tissues HepG2 cell, SMMC-7721 cell

Type 2 innate lymphoid cell-derived amphiregulin regulates type II alveolar epithelial cell transdifferentiation in a mouse model of bronchopulmonary dysplasia. Hong-yan Lu WB Mouse 1:5000 lung MLE-12 cell

FGF12 regulates cell cycle gene expression and promotes follicular granulosa cell proliferation through ERK phosphorylation in geese. Xingyong Chen WB Geese 1:10000 granulosa cell

Dietary antioxidant quercetin overcomes the acquired resistance of Sorafenib in Sorafenib-resistant hepatocellular carcinoma cells through epidermal growth factor receptor signaling inactivation. Zhou Fuqiong WB Mouse，Human 1:10000 Huh7 cell-xenograft Huh7 cell

High-protein compound yogurt with quinoa improved clinical features and metabolism of high-fat diet–induced nonalcoholic fatty liver disease in mice. Lin Wang WB Mouse 1:2000 liver, ileal

MiR-3976 regulates HCT-8 cell apoptosis and parasite burden by targeting BCL2A1 in response to Cryptosporidium parvum infection. Rongjun Wang WB Human 1:5000 HCT-8 cell

Critical role of MXRA7 in differentiation blockade in human acute promyelocytic leukemia cells. Yiqiang Wang WB Human human acute promyelocytic leukemia (APL) samples MOLM-13 cell, MEG01 cell, MV-411 cell,NB4 cell

Gastroprotective effect of eupatilin, a polymethoxyflavone from Artemisia argyi H.Lév. & Vaniot, in ethanol-induced gastric mucosal injury via NF-κB signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY Dali Meng WB Mouse，Rat gastric tissues RAW264.7 cell

Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells. Molecular Oncology Qiaoxia Zhang WB Human OCI/AML3 cell,NB4 cell，MOLM-13 cell

Dietary supplementation of sodium butyrate enhances lactation performance by promoting nutrient digestion and mammary gland development in dairy cows. Animal Nutrition Qiang Liu WB Bovine 1:5000 mammary gland tissues

LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes via sponging miR-1934-3p. CELL BIOLOGY AND TOXICOLOGY Xu Shiwen WB Mouse 1:10000 AML-12 cell

Placenta-derived exosomal miR-135a-5p promotes gestational diabetes mellitus pathogenesis by activating PI3K/AKT signalling pathway via SIRT1. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Jianying Yan WB Human plasma，placenta tissue HTR-8/SVneo cell

Chlorpyrifos-mediated mitochondrial calcium overload induces EPC cell apoptosis via ROS/AMPK/ULK1. FISH & SHELLFISH IMMUNOLOGY Shiwen Xu WB Fish 1:8000 epithelioma papulosum cyprini (EPC) cell

Secretory IgA-ETEC F5 Immune Complexes Promote Dendritic Cell Differentiation and Prime T Cell Proliferation in the Mouse Intestine. Life-Basel Liyun Yu WB Mouse 1:10000 Feces

YAP1 affects the prognosis through the regulation of stemness in endometrial cancer. PeerJ Rui Yuan WB Human HEC1-A cell, Ishikawa cell

Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc. CELLULAR SIGNALLING Zhimin Yin WB Human MCF-7 cell

Aedes albopictus salivary adenosine deaminase is an immunomodulatory factor facilitating dengue virus replication. Scientific Reports Jiahong Wu WB Mosquito，Human 1:2000 Salivary gland THP-1 cell

Efectos Protectores y Mecanismos de la Decocción de Huangqi Contra los Efectos Secundarios Inducidos por la Radiación. INTERNATIONAL JOURNAL OF MORPHOLOGY WB Rat brain,kidney

Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma Cancer Communications Xiaoteng Cui WB Human 1:10000 TBD0220 cell,U-87 MG cell

Boosting Mouse Defense against Lethal Toxoplasma gondii Infection with Full-Length and Soluble SAG1 Recombinant Protein Vaccines Xiang Li ELISA Mouse serum

Hexadecanamide alleviates Staphylococcus aureus-induced mastitis in mice by inhibiting inflammatory responses and restoring blood-milk barrier integrity PLoS Pathogens Lijuan Bao WB Mouse 1:20000 mammary gland,colon HC11 cell

Triptolide attenuates CCL4-induced liver fibrosis by regulating the differentiation of CD4+ T cells in mice INTERNATIONAL IMMUNOPHARMACOLOGY Shiyuan Jiang WB Mouse liver tissue

Inhibiting CBP Decreases AR Expression and Inhibits Proliferation in Benign Prostate Epithelial Cells Biomedicines Xingxing Tang WB Human 1:10000 BPH-1 cell,RWPE-1 cell

Profile of the bile acid FXR-FGF15 pathway in the glucolipid metabolism disorder of diabetic mice suffering from chronic stress PeerJ Weijia Cai WB Mouse 1:5000 liver,ileum

The BRAFV600E mutation maintains the aggressiveness of papillary thyroid cancers requiring downregulation of primary cilia MOLECULAR AND CELLULAR ENDOCRINOLOGY Cheng-Xu Ma IF Human 1:200 thyroid tumor tissue

TSTA3 overexpression promotes malignant characteristics in LUSC by regulating LAMP2-mediated autophagy and tumor microenvironment Cancer Cell International Guo Yanlin WB Human 1:10000 A549 cell,NCIH1299 cell,NCIH1650 cell,NCIH1975 cell,NCIH226 cell,NCIH1703 cell,SKMES1 cell

HgCl2 exposure mediates pyroptosis of HD11 cells and promotes M1 polarization and the release of inflammatory factors through ROS/Nrf2/NLRP3 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Jiaqi Wang WB Chicken 1:100000 HD11 cell

Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells iScience Zhe Cheng WB Human Colorectal cancer (CRC) tissue FHC cell,SW480 cell,SW620 cell,HCT116 cell

Danlou Recipe promotes cholesterol efflux in macrophages RAW264.7 and reverses cholesterol transport in mice with hyperlipidemia induced by P407 BMC Complementary Medicine and Therapies Han Wenrun WB Mouse 1:3000 liver tissue RAW264.7 cell

Effects of nanoselenium supplementation on lactation performance, nutrient digestion and mammary gland development in dairy cows ANIMAL BIOTECHNOLOGY Yapeng Liu WB Bovine 1:5000 mammary gland tissue

Spinosin inhibits activated hepatic stellate cell to attenuate liver fibrosis by targeting Nur77/ASK1/p38 MAPK signaling pathway EUROPEAN JOURNAL OF PHARMACOLOGY Gang Lin WB Human,Mouse liver tissue LX-2 cell,HSC-T6 cell

Mechanism of NO2-induced migraine in rats: The exploration of the role of miR-653-3p/IGF1 axis JOURNAL OF HAZARDOUS MATERIALS Shuzi Ye WB Rat 1:10000 trigeminal ganglion primary trigeminal ganglion neurons (PTGNs)

A GAPDH serotonylation system couples CD8+ T cell glycolytic metabolism to antitumor immunity MOLECULAR CELL Xu Wang WB Mouse 1:10000 CD8+ T cell,EL4 cell

Calcium supplementation attenuates fluoride-induced bone injury via PINK1/Parkin-mediated mitophagy and mitochondrial apoptosis in mice JOURNAL OF HAZARDOUS MATERIALS Yingjun Hu WB Mouse 1:8000 femur tissue

Paracrine signaling of ferroptotic airway epithelium in crystalline silica-induced pulmonary fibrosis augments local fibroblast activation through glycolysis reprogramming ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Qianmin Li WB Mouse,Human lung tissue HBE cell,MRC-5 cell

IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3 MOLECULAR MEDICINE Zhu Ying WB Mouse 1:5000 lung tissue

Huangqi Baihe Granules alleviate hypobaric hypoxia-induced acute lung injury in rats by suppressing oxidative stress and the TLR4/NF-κB/NLRP3 inflammatory pathway JOURNAL OF ETHNOPHARMACOLOGY Yuanding Zeng WB Rat 1:10000 lung tissue

CK1δ/ε inhibition induces ULK1-mediated autophagy in tumorigenesis Translational Oncology Vivian Weiwen Xue WB Human A549 cell,HEK293 cell

The plasma derived exosomal miRNA-483-5p/502-5p serve as potential MCI biomarkers in aging EXPERIMENTAL GERONTOLOGY Ting Liu WB Human plasma

Cadmium Exposure Induces Apoptosis and Necrosis of Thyroid Cells via the Regulation of miR-494-3p/PTEN Axis BIOLOGICAL TRACE ELEMENT RESEARCH Zhao Jinghua WB Pig 1:10000 thyroid tissue

Lamin B1: a novel biomarker in adult and pediatric adrenocortical carcinoma ENDOCRINE-RELATED CANCER Yihao Chen WB Human 1:5000 SW13 cell,H295R cell

Exercise Alleviates Fluoride-Induced Learning and Memory Impairment in Mice: Role of miR-206-3p and PREG BIOLOGICAL TRACE ELEMENT RESEARCH Chai Lei WB Mouse 1:10000 HT-22 cell

STMN1 Promotes Tumor Metastasis in Non-small Cell Lung Cancer Through Microtubule-dependent And Nonmicrotubule-dependent Pathways International Journal of Biological Sciences Lizhong Zeng ICC Human 1:500 NCI-H1299 cell,PC-9 cell

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells Cell Death & Disease Dou Zhihui WB Human 1:10000 Human glioma stem cell-like cells (GSCS),A172 cell,T98G cell,U251 cell,U87 cell,HA1800 cell

9-O-monoethyl succinate berberine effectively blocks the PI3K/AKT signaling pathway by targeting Wnt5a protein in inhibiting osteosarcoma growth PHYTOMEDICINE Yanquan Wang WB Mouse,Human 143B cell,HOS cell,bone marrow mesenchymal stem cells (BMSCs)

The C4 Protein of TbLCYnV Promotes SnRK1 β2 Degradation Via the Autophagy Pathway to Enhance Viral Infection in N. benthamiana Viruses-Basel Xinquan Li WB Nicotiana benthamiana leaf

An Inulin-Type Fructan CP-A from Codonopsis pilosula Alleviated 5-Fluorouracil-Induced Intestinal Mucositis via the ERK/MLCK/MLC2 Pathway and Regulation of Gut Microbiota Pharmaceuticals Jiangtao Zhou IHC,WB Rat small-intestine tissues IEC-6 cell

Ultrasound triggered local sequential reactive oxygen species and nitric oxide release for enhanced cerasomal drug delivery CHEMICAL ENGINEERING JOURNAL Ruiqi Wu IF Mouse 1:200 4T1 cell-Xenograft

Depletion of the N6-Methyladenosine (m6A) reader protein IGF2BP3 induces ferroptosis in glioma by modulating the expression of GPX4 Cell Death & Disease Deng Limei WB Human U87 cell,HEK 293 T cell,HS683 cell

T-2 toxin induces cardiac fibrosis by causing metabolic disorders and up-regulating Sirt3/FoxO3α/MnSOD signaling pathway-mediated oxidative stress Journal of Environmental Sciences Lichun Qiao WB Rat cardiac tissue

Unraveling the immune landscape and therapeutic biomarker PMEPA1 for oxaliplatin resistance in colorectal cancer: A comprehensive approach BIOCHEMICAL PHARMACOLOGY Zhengguang Zhang WB Mouse,Human 1:10000 HCT116R cell-Xenograft HCT116 cell

Protective Effect of Mesenchymal Stem Cell Active Factor Combined with Alhagi maurorum Extract on Ulcerative Colitis and the Underlying Mechanism INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Xuanhong Cao WB Mouse 1:3000 colon tissue

Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes EUROPEAN JOURNAL OF PHARMACOLOGY Lei Zhu WB Mouse B16 cell-Xenograft B16 cell,MC38 cell

Exploring the Role of the CapG Gene in Hypoxia Adaptation in Tibetan Pigs Frontiers in Genetics Yan Feifei WB Pig 1:10000 lung tissue

IRF4-mediated Treg phenotype switching can aggravate hyperoxia-induced alveolar epithelial cell injury BMC Pulmonary Medicine Langyue He WB Mouse 1:5000 lung tissue

Combined exposure of emamectin benzoate and microplastics induces tight junction disorder, immune disorder and inflammation in carp midgut via lysosome/ROS/ferroptosis pathway WATER RESEARCH Xu Shi WB Fish 1:100000 midgut tissue Epithelioma papulosum cyprini (EPC) cell

Expression of CCL2 signaling pathway genes in patients with periodontitis and atherosclerosis HISTOLOGY AND HISTOPATHOLOGY Yuxia Zhao IHC Human gingival tissue

Outer membrane vesicles generated by an exogenous bacteriophage lysin and protection against Acinetobacter baumannii infection JOURNAL OF NANOBIOTECHNOLOGY Changchang Li WB Gram-negative bacteria Acinetobacter baumannii

Co-exposure of decabromodiphenyl ethane and polystyrene nanoplastics damages grass carp (Ctenopharyngodon idella) hepatocytes: Focus on the role of oxidative stress, ferroptosis, and inflammatory reaction SCIENCE OF THE TOTAL ENVIRONMENT Bendong Shi WB Fish Ctenopharyngodon idella hepatocytes (L8824 cells)

GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB JOURNAL OF VIROLOGY Xiaoran Chang WB Human,Monkey Vero cell,293T cell

Advantages of pulsed electric field ablation for COPD: Excellent killing effect on goblet cells BIOELECTROCHEMISTRY Haoyang Zhu WB Human 1:20000 BEAS-2B cell

The FGF6 amplification mutation plays an important role in the progression and treatment of malignant meningioma Translational Oncology Ruihao Liang WB Human 1:10000 IOMM-LEE cell,CH157MN cell

Fe3O4@SiO2-Protein A-oHSV/CD63 Ab for Capturing Virus and Exosomes Journal of Analysis and Testing Zheng Wenqing WB Human Huq 7 cell

Aerobic exercise improves motor dysfunction in Parkinson's model mice via differential regulation of striatal medium spiny neuron Scientific Reports Yinhao Wang IF Mouse 1:500 brain tissue

Exosomal miRNA-26b-5p from PRP suppresses NETs by targeting MMP-8 to promote diabetic wound healing JOURNAL OF CONTROLLED RELEASE Shunli Rui WB Mouse,Human 1:10000 skin tissue,platelet-rich plasma (PRP) neutrophils

Study on the mechanism of modified Gegen Qinlian decoction in regulating the intestinal flora-bile acid-TGR5 axis for the treatment of type 2 diabetes mellitus based on macro genome sequencing and targeted metabonomics integration PHYTOMEDICINE Rong Liu

Astragaloside IV mediates radiation-induced neuronal damage through activation of BDNF-TrkB signaling PHYTOMEDICINE Xin Liu WB Mouse,Rat 1:10000 PC12 cell,cortical neurons

Genome editing in plants using the TnpB transposase system aBIOTECH Li Qi WB Rice 1:5000 leaf

The flavonoids from the fruits of Psoralea corylifolia and their potential in inhibiting metastasis of human non-small cell lung cancers BIOORGANIC CHEMISTRY Peixin Shi WB Human A549 cell

The Cellular Microbiome of Visceral Organs: An Inherent Inhabitant of Parenchymal Cells Microorganisms Xiaowei Sun WB Rat 1:5000 liver tissue, spleen tissue, kidney tissue, pancreas tissue, heart tissue, lung tissue, skeletal muscle tissue, brain tissue, intestinal tissue

Chlormequat chloride induces hepatic steatosis by promoting mTOR/SREBP1 mediated lipogenesis via AMPK inhibition FOOD AND CHEMICAL TOXICOLOGY Chengping Kang WB Rat,Human liver tissue HepG2 cell

IKBIP promotes tumor development via the akt signaling pathway in esophageal squamous cell carcinoma BMC CANCER Hu Jiannan WB Human KYSE-150 cell,KYSE-30 cell

Virus-Mimetic Extracellular-Vesicle Vaccine Boosts Systemic and Mucosal Immunity via Immune Recruitment ACS Nano Jingru Li ELISA,WB Mouse 1:5000 extracellular vesicles

Mitochondria-targeted drug delivery system based on tetrahedral framework nucleic acids for bone regeneration under oxidative stress CHEMICAL ENGINEERING JOURNAL Yanjing Li WB Rat Primary periodontal stem cell(PDLSC)

SQSTM1 improves acute lung injury via inhibiting airway epithelium ferroptosis in a vitamin D receptor / autophagy-mediated manner FREE RADICAL BIOLOGY AND MEDICINE Youjing Yang IHC,IF Mouse,Human lung tissue HBE cell

DHA dietary intervention caused different hippocampal lipid and protein profile in ApoE-/- and C57BL/6J mice BIOMEDICINE & PHARMACOTHERAPY Lu Liu IHC Mouse 1:2000 brain tissue

Influences of lauric acid addition on performance, nutrient digestibility and proteins related to mammary gland development in dairy cows Animal Nutrition Jing Zhang WB Bovine 1:5000 mammary tissue

MiR-199a-3p regulates HCT-8 cell autophagy and apoptosis in response to Cryptosporidium parvum infection by targeting MTOR Communications Biology Wu Shanbo WB Human 1:5000 HCT-8 cell

AQP4- and Kir4.1-Mediated Müller Cell Oedema Is Involved in Retinal Injury Induced By Hypobaric Hypoxia MOLECULAR NEUROBIOLOGY Han Cong WB Mouse 1:10000 retinal tissue

Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway Frontiers in Pharmacology Jia Yanjun WB Rat PC12 cell

The potential benefits of PGC-1α in treating Alzheimer's disease are dependent on the integrity of the LLKYL L3 motif: Effect of regulating mitochondrial axonal transportation EXPERIMENTAL GERONTOLOGY Hou-Zhen Shi WB Human brain tissue

M2 macrophages promote PD-L1 expression in triple-negative breast cancer via secreting CXCL1 PATHOLOGY RESEARCH AND PRACTICE Lifen Zhang WB Human MDA-MB-231 cell,SUM159 cell,THP-1 cell

The Global Landscapes of Lysine Crotonylation in Pseudorabies Virus Infection VIROLOGY Xiaoyong Chen WB Human HEK293T cell

A ferritin-based nanoparticle displaying a neutralizing epitope for foot-and-mouth disease virus (FMDV) confers partial protection in guinea pigs BMC Veterinary Research Lu Bingzhou ELISA Mouse 1:5000 sera

H3K18 Lactylation Potentiates Immune Escape of Non-Small Cell Lung Cancer CANCER RESEARCH Zhang Cai WB Human,Mouse non-small cell lung cancer (NSCLC) tissue,LLC cell-xenograft A549 cell,NCI-H1299 cell,NCI-H1703 cell,NCI-H1944 cell,NCI-H1975 cell,NCI-H358 cell,PC-9 cell,BEAS-2B cell

FOSL1-mediated LINC01566 negatively regulates CD4+ T-cell activation in myasthenia gravis Journal of Neuroinflammation Li Lifang WB Human 1:10000 Jurkat cell

DDX19A promotes gastric cancer cell proliferation and migration by activating the PI3K/AKT pathway Cancer Cell International Cheng Yu WB Human 1:10000 Gastric cancer (GC) tissue GES-1 cell,MGC-803 cell,BGC-823 cell,HGC-27 cell,AGS cell

Plantaginis Semen Ameliorates Hyperuricemia Induced by Potassium Oxonate INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Tian Liu WB Rat 1:5000 kidney tissue

TRIM103 activates the RLRs pathway to enhance antiviral response by targeting VP5 and VP7 DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY Beibei Qin WB Fish 1:2000 tenopharyngodon idella kidney (CIK) cell

The Neuroprotective and Anxiolytic Effects of Magnesium Sulfate on Retinal Dopaminergic Neurons in 6-OHDA-Induced Parkinsonian Rats: A Pilot Study Brain Sciences Leyi Huang WB Rat 1:5000 eye tissue

Kaempferol inhibited invasion and metastasis of gastric cancer cells by targeting AKT/GSK3β pathway based on network pharmacology and molecular docking JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH Xia-Qing Gao WB Human 1:10000 HGC27 cell,MKN45 cell

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