• Target：
• ABR

• Gene Name：
• ABR

• Protein Name：
• ABR

• Human Gene Id：
• 29

• Human Swiss Prot No：
• Q12979

• Mouse Gene Id：
• 109934

• Mouse Swiss Prot No：
• Q5SSL4

• Immunogen：
• Synthesized peptide derived from human ABR AA range: 393-443

• Specificity：
• This antibody detects endogenous levels of ABR at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 94kD

• Background：
• This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012],

• Function：
• function:GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them.,similarity:Contains 1 C2 domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Highly enriched in the brain. Much weaker expression in heart, lung and muscle.,

• Subcellular Location：
• Cell projection, dendritic spine . Cell projection, axon . Cell junction, synapse .

• Expression：
• Highly enriched in the brain. Much weaker expression in heart, lung and muscle.

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