ZFP57 rabbit pAb
- Catalog No.:YT7618
- Applications:WB
- Reactivity:Human;Mouse;Rat
- Target:
- ZFP57
- Fields:
- >>Herpes simplex virus 1 infection
- Gene Name:
- ZFP57 C6orf40 ZNF698
- Protein Name:
- ZFP57
- Human Gene Id:
- 346171
- Human Swiss Prot No:
- Q9NU63
- Mouse Gene Id:
- 22715
- Mouse Swiss Prot No:
- Q8C6P8
- Rat Gene Id:
- 361783
- Rat Swiss Prot No:
- A0JPK3
- Immunogen:
- Synthesized peptide derived from human ZFP57 AA range: 373-423
- Specificity:
- This antibody detects endogenous levels of ZFP57 at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 50kD
- Background:
- The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009],
- Function:
- disease:Defects in ZFP57 are the cause of transient neonatal diabetes mellitus type 1 (TNDM1) [MIM:601410]. Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. The major cause of TNDM1 is aberrant expression of imprinted genes at chromosome 6q24, associated in 20% of cases with DNA hypomethylation at the transient neonatal diabetes differentially methylated region (DMR), which lies within the imprinted promoter of the PLAGL1 gene. Over 50% of individuals with transient neonatal diabetes and hypomethylation at 6q24 also show mosaic DNA hypomethylation at other imprinted loci throughout the genome and a range of additional clinical features.,domain:The KRAB domain
- Subcellular Location:
- Nucleus . Binds various differentially methylated regions (DMR). .
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night