• Target：
• PNCB

• Fields：
• >>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors

• Gene Name：
• NAPRT1 FHIP

• Protein Name：
• PNCB

• Human Gene Id：
• 93100

• Human Swiss Prot No：
• Q6XQN6

• Mouse Gene Id：
• 223646

• Mouse Swiss Prot No：
• Q8CC86

• Rat Gene Id：
• 315085

• Rat Swiss Prot No：
• Q6XQN1

• Immunogen：
• Synthesized peptide derived from human PNCB AA range: 134-184

• Specificity：
• This antibody detects endogenous levels of PNCB at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 59kD

• Background：
• Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008],

• Function：
• catalytic activity:Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.,function:Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.,pathway:Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate ribonucleotide from nicotinate: step 1/1.,similarity:Belongs to the NAPRTase family.,

• Subcellular Location：
• Cytoplasm, cytosol .

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