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- FXL18 rabbit pAb
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FXL18 rabbit pAb
- Catalog No.:YT7528
- Applications:WB
- Reactivity:Human
- Immunogen:
- Synthesized peptide derived from human FXL18 AA range: 7-57
- Specificity:
- This antibody detects endogenous levels of FXL18 at Human
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 89kD
- Background:
- The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016],
- Function:
- function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 3 LRR (leucine-rich) repeats.,subunit:Directly interacts with SKP1A and CUL1.,
![](/uploadfiles/PIC/YT7528wb-2019.jpg)
- Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night