• Target：
• FBXW2

• Gene Name：
• FBXW2 FBW2 FWD2

• Protein Name：
• FBXW2

• Human Gene Id：
• 26190

• Human Swiss Prot No：
• Q9UKT8

• Mouse Swiss Prot No：
• Q60584

• Rat Gene Id：
• 311881

• Rat Swiss Prot No：
• B2RZ17

• Immunogen：
• Synthesized peptide derived from human FBXW2 AA range: 155-205

• Specificity：
• This antibody detects endogenous levels of FBXW2 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 50kD

• Background：
• F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008],

• Function：
• function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 4 WD repeats.,subunit:Directly interacts with SKP1A and CUL1.,

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