DBC1 rabbit pAb
- Catalog No.:YT7255
- Applications:WB
- Reactivity:Human;Mouse;Rat
- Target:
- DBC1
- Gene Name:
- DBC1 DBCCR1 FAM5A IB3089A
- Protein Name:
- DBC1
- Human Gene Id:
- 1620
- Human Swiss Prot No:
- O60477
- Mouse Gene Id:
- 56710
- Mouse Swiss Prot No:
- Q920P3
- Rat Gene Id:
- 140610
- Rat Swiss Prot No:
- Q925T8
- Immunogen:
- Synthesized peptide derived from human DBC1 AA range: 100-150
- Specificity:
- This antibody detects endogenous levels of DBC1 at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 84kD
- Background:
- This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. [provided by RefSeq, Jul 2008],
- Function:
- function:Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.,miscellaneous:DBC1 is silenced by methylation in 50% of bladder cancer cell lines.,similarity:Belongs to the FAM5 family.,similarity:Contains 1 MACPF domain.,tissue specificity:Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.,
- Subcellular Location:
- Cytoplasm .
- Expression:
- Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night