• Target：
• TIM8B

• Gene Name：
• TIMM8B DDP2 DDPL TIM8B

• Protein Name：
• TIM8B

• Human Gene Id：
• 26521

• Human Swiss Prot No：
• Q9Y5J9

• Mouse Gene Id：
• 30057

• Mouse Swiss Prot No：
• P62077

• Rat Gene Id：
• 64372

• Rat Swiss Prot No：
• P62078

• Immunogen：
• Synthesized peptide derived from human TIM8B AA range: 1-51

• Specificity：
• This antibody detects endogenous levels of TIM8B at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1：50-200. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 9kD

• Background：
• This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009],

• Function：
• domain:The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.,function:Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.,similarity:Belongs to the small Tim family.,subunit:Heterohexamer; possibl

• Subcellular Location：
• Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side .

• Expression：
• Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.

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