PMM1 rabbit pAb
- Catalog No.:YT7034
- Applications:WB;IHC
- Reactivity:Human;Mouse
- Target:
- PMM1
- Fields:
- >>Fructose and mannose metabolism;>>Amino sugar and nucleotide sugar metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Biosynthesis of nucleotide sugars
- Gene Name:
- PMM1 PMMH22
- Protein Name:
- PMM1
- Human Gene Id:
- 5372
- Human Swiss Prot No:
- Q92871
- Mouse Gene Id:
- 29858
- Mouse Swiss Prot No:
- O35621
- Immunogen:
- Synthesized peptide derived from human PMM1 AA range: 18-68
- Specificity:
- This antibody detects endogenous levels of PMM1 at Human/Mouse
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000;IHC 1:50-300
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 29kD
- Background:
- Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. [provided by RefSeq, Jul 2008],
- Function:
- catalytic activity:Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.,function:Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.,pathway:Nucleotide-sugar biosynthesis; GDP-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.,similarity:Belongs to the eukaryotic PMM family.,tissue specificity:Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle.,
- Subcellular Location:
- Cytoplasm .
- Expression:
- Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle.
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
- Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).