CDC26 rabbit pAb
- Catalog No.:YT6979
- Applications:IHC;IF
- Reactivity:Human;Mouse;Rat
- Target:
- CDC26
- Fields:
- >>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>Progesterone-mediated oocyte maturation;>>Human T-cell leukemia virus 1 infection
- Gene Name:
- CDC26 ANAPC12 C9orf17
- Protein Name:
- CDC26
- Human Gene Id:
- 246184
- Human Swiss Prot No:
- Q8NHZ8
- Mouse Gene Id:
- 66440
- Mouse Swiss Prot No:
- Q99JP4
- Rat Gene Id:
- 366381
- Rat Swiss Prot No:
- Q6YDN7
- Immunogen:
- Synthesized peptide derived from human CDC26 AA range: 21-71
- Specificity:
- This antibody detects endogenous levels of CDC26 at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- IHC 1:50-200. IF 1:50-200
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 9kD
- Background:
- The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008],
- Function:
- function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase that controls progression through mitosis and the G1 phase of the cell cycle. May recruit the E2 ubiquitin-conjugating enzymes to the complex.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CDC26 family.,subunit:The APC/C is composed of at least 11 subunits.,
- Subcellular Location:
- Nucleus .
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- Antibody-FAQs
- Products Images
- Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).