• Target：
• SPG16

• Gene Name：
• SPAG16 PF20

• Protein Name：
• SPG16

• Human Gene Id：
• 79582

• Human Swiss Prot No：
• Q8N0X2

• Mouse Gene Id：
• 66722

• Mouse Swiss Prot No：
• Q8K450

• Immunogen：
• Synthesized peptide derived from human SPG16 AA range: 520-570

• Specificity：
• This antibody detects endogenous levels of SPG16 at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 69kD

• Background：
• Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008],

• Function：
• function:Necessary for sperm flagellar function.,similarity:Contains 7 WD repeats.,subcellular location:Detected on the sperm flagellum. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules.,subunit:Interacts with SPAG6.,tissue specificity:Isoform 1 is detected in testis. Isoform 4 is detected in testis and brain, and at lower levels in kidney, heart, pancreas, thyroid, ovary, adrenal gland, spinal cord, trachea and liver.,

• Subcellular Location：
• Cytoplasm . Cytoplasm, cytoskeleton, flagellum axoneme . Cytoplasm, cytoskeleton, cilium axoneme . Cell projection, cilium, flagellum . Detected on the sperm flagellum axoneme. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules (By similarity). .

• Expression：
• Isoform 1 is detected in testis. Isoform 4 is detected in testis and brain, and at lower levels in kidney, heart, pancreas, thyroid, ovary, adrenal gland, spinal cord, trachea and liver.

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