• Target：
• JAZF1

• Gene Name：
• JAZF1 TIP27 ZNF802

• Protein Name：
• JAZF1

• Human Gene Id：
• 221895

• Human Swiss Prot No：
• Q86VZ6

• Mouse Gene Id：
• 231986

• Mouse Swiss Prot No：
• Q80ZQ5

• Immunogen：
• Synthesized peptide derived from human JAZF1 AA range: 57-107

• Specificity：
• This antibody detects endogenous levels of JAZF1 at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 27kD

• Background：
• This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008],

• Function：
• disease:A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.,function:Potential transcription factor.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interacts with TAK1.,

• Subcellular Location：
• Nucleus .

• Expression：
• Highest expression in testis with moderate levels in colon, placenta, prostate and ovary and low levels in brain, spleen, liver and small intestine.

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