• Target：
• RPH3L

• Gene Name：
• RPH3AL NOC2

• Protein Name：
• RPH3L

• Human Gene Id：
• 9501

• Human Swiss Prot No：
• Q9UNE2

• Mouse Gene Id：
• 380714

• Mouse Swiss Prot No：
• Q768S4

• Rat Gene Id：
• 171123

• Rat Swiss Prot No：
• O54880

• Immunogen：
• Synthesized peptide derived from human RPH3L AA range: 162-212

• Specificity：
• This antibody detects endogenous levels of RPH3L at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 35kD

• Background：
• The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010],

• Function：
• domain:The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A.,function:Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 RabBD (Rab-binding) domain.,subcellular location:Recruited to the vesicle membrane in a GTP-and RAB3B-dependent manner in epithelial cells.,subunit:Recruited to dense-core vesicles through specific interaction with RAB27A in endocrine cells. Interacts with RAB3A, RAB3B, RAB3C and RAB3D. Interacts with ZYX.,tissue specificity:Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells.,

• Subcellular Location：
• Cytoplasm . Cytoplasmic vesicle, secretory vesicle membrane . Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells.

• Expression：
• Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells.

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