• Target：
• NKD2

• Fields：
• >>Wnt signaling pathway;>>Hippo signaling pathway

• Gene Name：
• NKD2

• Protein Name：
• NKD2

• Human Gene Id：
• 85409

• Human Swiss Prot No：
• Q969F2

• Mouse Gene Id：
• 72293

• Mouse Swiss Prot No：
• Q8VE28

• Immunogen：
• Synthesized peptide derived from human NKD2 AA range: 311-361

• Specificity：
• This antibody detects endogenous levels of NKD2 at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 50kD

• Background：
• This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012],

• Function：
• developmental stage:Expressed in fetal kidney and lung.,function:Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.,similarity:Belongs to the NKD family.,similarity:Contains 1 EF-hand domain.,subunit:Interacts with DVL1, DVL2, DVL3 and PPP2R3A (By similarity). Interacts with TGFA.,tissue specificity:Expressed in kidney, lung, pancreas and spleen.,

• Subcellular Location：
• Cell membrane . Cytoplasm . Cytoplasmic vesicle .

• Expression：
• Expressed in kidney, lung, pancreas and spleen.

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