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- FRPD2 rabbit pAb
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FRPD2 rabbit pAb
- Catalog No.:YT6860
- Applications:WB
- Reactivity:Human
- Gene Name:
- FRMPD2 PDZD5C PDZK4 PDZK5C
- Immunogen:
- Synthesized peptide derived from human FRPD2 AA range: 1161-1211
- Specificity:
- This antibody detects endogenous levels of FRPD2 at Human
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 144kD
- Background:
- This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009],
- Function:
- caution:Could be the product of a pseudogene. This is the product of related genes or pseudogenes located in a region of chromosome 10q which contains a segmental duplication resulting in three nearly identical regions.,similarity:Contains 1 FERM domain.,similarity:Contains 1 KIND domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 2 PDZ (DHR) domains.,similarity:Contains 3 PDZ (DHR) domains.,
- Subcellular Location:
- Cytoplasm . Basolateral cell membrane . Cell junction, tight junction . Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes with TJP1 at tight junctions. Its recruitment to cell-cell contacts requires CDH1.
- Expression:
- Expressed in epithelial cells.
![](/uploadfiles/PIC/YT6860wb-2019.jpg)
- Western blot analysis of lysates from THP-1 cells, primary antibody was diluted at 1:1000, 4°over night