• Target：
• COTL1

• Gene Name：
• COTL1 CLP

• Protein Name：
• COTL1

• Human Gene Id：
• 23406

• Human Swiss Prot No：
• Q14019

• Mouse Gene Id：
• 72042

• Mouse Swiss Prot No：
• Q9CQI6

• Rat Gene Id：
• 361422

• Rat Swiss Prot No：
• B0BNA5

• Immunogen：
• Synthesized peptide derived from human COTL1 AA range: 29-79

• Specificity：
• This antibody detects endogenous levels of COTL1 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 16kD

• Background：
• This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008],

• Function：
• function:Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization.,similarity:Belongs to the actin-binding proteins ADF family. Coactosin subfamily.,similarity:Contains 1 ADF-H domain.,subunit:Interacts with 5-lipoxygenase (5LO) in a calcium-independent manner.,tissue specificity:Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.,

• Subcellular Location：
• Cytoplasm . Cytoplasm, cytoskeleton . Nucleus .

• Expression：
• Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.

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