• Target：
• CAR16

• Fields：
• >>NOD-like receptor signaling pathway

• Gene Name：
• CARD16 COP COP1

• Protein Name：
• CAR16

• Human Gene Id：
• 114769

• Human Swiss Prot No：
• Q5EG05

• Immunogen：
• Synthesized peptide derived from human CAR16 AA range: 101-151

• Specificity：
• This antibody detects endogenous levels of CAR16 at Human

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 22kD

• Function：
• function:Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.,induction:Down-regulated in patients suffering of Huntington disease.,similarity:Contains 1 CARD domain.,subunit:Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2.,tissue specificity:Widely expressed. Expressed at higher level in placenta, spleen, lymph

• Expression：
• Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.

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