• Target：
• OSBL8

• Gene Name：
• OSBPL8 KIAA1451 ORP8 OSBP10

• Protein Name：
• OSBL8

• Human Gene Id：
• 114882

• Human Swiss Prot No：
• Q9BZF1

• Immunogen：
• Synthesized peptide derived from human OSBL8 AA range: 290-340

• Specificity：
• This antibody detects endogenous levels of OSBL8 at Human

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 98kD

• Background：
• This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],

• Function：
• similarity:Belongs to the OSBP family.,similarity:Contains 1 PH domain.,tissue specificity:Widely expressed.,

• Subcellular Location：
• [Isoform 1]: Endoplasmic reticulum membrane ; Single-pass membrane protein . Nucleus membrane . The presence of the N-terminus extension contains an overall negative charge that may explain the weak localization to the cortical endoplasmic reticulum (Probable). .; [Isoform 3]: Endoplasmic reticulum membrane ; Single-pass membrane protein. Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites. .

• Expression：
• Widely expressed (PubMed:11735225). Expressed at higher level in macrophages (PubMed:17991739).

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