• Target：
• Lefty

• Fields：
• >>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells

• Gene Name：
• LEFTY1/LEFTY2

• Protein Name：
• Left-right determination factor 1/Left-right determination factor 2

• Human Gene Id：
• 10637/7044

• Human Swiss Prot No：
• O75610/O00292

• Mouse Gene Id：
• 13590/320202

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the C-terminal region of human LEFTY1/LEFTY2. AA range:301-350

• Specificity：
• Lefty Polyclonal Antibody detects endogenous levels of Lefty protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• LEFTY1;LEFTB;LEFTYB;Left-right determination factor 1;Left-right determination factor B;Protein lefty-1;Protein lefty-B;LEFTY2;EBAF;LEFTA;LEFTYA;TGFB4;PSEC0024;Left-right determination factor 2;Endometrial bleeding-associated factor;Left-right determination factor A;Protein lefty-2;Protein lefty-A;Transforming growth factor beta-4;TGF-beta-4

• Observed Band(KD)：
• 40kD

• Background：
• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016],

• Function：
• function:Required for left-right axis determination as a regulator of LEFTY2 and NODAL.,PTM:The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.,similarity:Belongs to the TGF-beta family.,

• Subcellular Location：
• Secreted.

• Expression：
• Colon,Pancreas,Spleen,Teratocarcinoma,

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