• Target：
• CD223

• Gene Name：
• LAG3

• Protein Name：
• Lymphocyte activation gene 3 protein

• Human Gene Id：
• 3902

• Human Swiss Prot No：
• P18627

• Mouse Gene Id：
• 16768

• Mouse Swiss Prot No：
• Q61790

• Rat Gene Id：
• 297596

• Rat Swiss Prot No：
• Q5BK54

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human LAG3. AA range:91-140

• Specificity：
• CD223 Polyclonal Antibody detects endogenous levels of CD223 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• LAG3;FDC;Lymphocyte activation gene 3 protein;LAG-3;Protein FDC;CD223

• Observed Band(KD)：
• 57kD

• Background：
• Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008],

• Function：
• function:Involved in lymphocyte activation. Binds to HLA class-II antigens.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:On cell surface of activated NK and T-lymphocytes.,

• Subcellular Location：
• [Lymphocyte activation gene 3 protein]: Cell membrane ; Single-pass type I membrane protein .; [Secreted lymphocyte activation gene 3 protein]: Secreted . Produced following cleavage of the main chain. .

• Expression：
• Primarily expressed in activated T-cells and a subset of natural killer (NK) cells.

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