• Target：
• CyPB

• Gene Name：
• PPIB

• Protein Name：
• Peptidyl-prolyl cis-trans isomerase B

• Human Gene Id：
• 5479

• Human Swiss Prot No：
• P23284

• Mouse Gene Id：
• 19035

• Mouse Swiss Prot No：
• P24369

• Rat Gene Id：
• 64367

• Rat Swiss Prot No：
• P24368

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the C-terminal region of human PPIB. AA range:151-200

• Specificity：
• CyPB Polyclonal Antibody detects endogenous levels of CyPB protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PPIB;CYPB;Peptidyl-prolyl cis-trans isomerase B;PPIase B;CYP-S1;Cyclophilin B;Rotamase B;S-cyclophilin;SCYLP

• Observed Band(KD)：
• 24kD

• Background：
• The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009],

• Function：
• catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,caution:It is uncertain whether Met-1 or Met-9 is the initiator.,enzyme regulation:Cyclosporin A (CsA) inhibits CYPB.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,

• Subcellular Location：
• Virion . (Microbial infection).; Endoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .

• Expression：
• Brain,Fetal brain cortex,Prostate,Skin,

Liu, Jing, et al. "CYPB upregulates and promotes cell proliferation in endometrial carcinoma." (2020).

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