• Target：
• SP-A

• Fields：
• >>Phagosome;>>Pertussis

• Gene Name：
• SFTPA2/SFTPA1

• Protein Name：
• Pulmonary surfactant-associated protein A2/Pulmonary surfactant-associated protein A1

• Human Gene Id：
• 729238

• Human Swiss Prot No：
• Q8IWL1

• Rat Gene Id：
• 24773

• Rat Swiss Prot No：
• P08427

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human SFTPA1/2. AA range:141-190

• Specificity：
• SP-A Polyclonal Antibody detects endogenous levels of SP-A protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SFTPA2;COLEC5;PSAP;SFTP1;SFTPA;SFTPA2B;Pulmonary surfactant-associated protein A2;PSP-A;PSPA;SP-A;SP-A2;35 kDa pulmonary surfactant-associated protein;Alveolar proteinosis protein;Collectin-5;SFTPA1;COLEC4;PSAP;SFTP1;SFTPA;SFTPA1B;Pulmonary surfactant-associated protein A1;PSP-A;PSPA;SP-A;SP-A1;35 kDa pulmonary surfactant-associated protein;Alveolar proteinosis protein;Collectin-4

• Observed Band(KD)：
• 34kD

• Background：
• This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009],

• Function：
• function:In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.,miscellaneous:Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).,polymorphism:At least 6 alleles of SFTPA2 are known: 1A, 1A(0), 1A(1), 1A(2), 1A(3) and 1A(4). The sequence shown is that of allele 1A(0).,similarity:Belongs to the SFTPA family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 collagen-like domain.,subunit:Oligomeric complex of 6 set of homotrimers.,

• Subcellular Location：
• Secreted . Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.

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