• Target：
• TDAG51

• Gene Name：
• PHLDA1

• Protein Name：
• Pleckstrin homology-like domain family A member 1

• Human Gene Id：
• 22822

• Human Swiss Prot No：
• Q8WV24

• Mouse Gene Id：
• 21664

• Mouse Swiss Prot No：
• Q62392

• Rat Swiss Prot No：
• Q9QZA1

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PHLA1. AA range:271-320

• Specificity：
• TDAG51 Polyclonal Antibody detects endogenous levels of TDAG51 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PHLDA1;PHRIP;TDAG51;Pleckstrin homology-like domain family A member 1;Apoptosis-associated nuclear protein;Proline- and glutamine-rich protein;PQ-rich protein;PQR protein;Proline- and histidine-rich protein;T-cell death-associated

• Observed Band(KD)：
• 40kD

• Background：
• This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008],

• Function：
• function:Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.,induction:Induced by homocysteine and other ER stress-inducing reagents. Induced by phorbolester (TPA)/ionomycin, and stimulation of the T-cell receptor (TCR) complex in T-cells.,similarity:Contains 1 PH domain.,subcellular location:Colocalizes with intracellular vesicles.,subunit:Interacts with RPL14, EIF3S7 and PABPC4.,tissue specificity:Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).,

• Subcellular Location：
• Cytoplasm . Cytoplasmic vesicle . Nucleus, nucleolus . Colocalizes with intracellular vesicles. .

• Expression：
• Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).

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