SNX3 Polyclonal Antibody

    • Catalog No.:YT4359
    • Applications:WB,ELISA
    • Reactivity:Human,Mouse,Rat
      • Gene Name:
      • SNX3
      • Protein Name:
      • Sorting nexin-3
      • Human Gene Id:
      • 8724
      • Human Swiss Prot No:
      • O60493
      • Mouse Swiss Prot No:
      • O70492
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human SNX3. AA range:91-140
      • Specificity:
      • SNX3 Polyclonal Antibody detects endogenous levels of SNX3 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • SNX3; Sorting nexin-3; Protein SDP3
      • MolecularWeight(Da):
      • 18762
      • Observed Band(KD):
      • 18
      • Background:
      • sorting nexin 3(SNX3) Homo sapiens This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014],
      • Function:
      • disease:A chromosomal aberration disrupting SNX3 may be a cause of microphthalmia syndromic type 8 (MCOPS8) [MIM:601349]. Translocation t(6;13)(q21;q12). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS8 is a very rare congenital syndrome characterized by microcephaly, microphthalmia, ectrodactyly of the lower limbs and prognathism. Intellectual deficit has been reported.,function:May be involved in several stages of intracellular trafficking.,similarity:Belongs to the sorting nexin family.,similarity:Contains 1 PX (phox homology) domain.,
      • Subcellular Location:
      • cytoplasm,early endosome,cytosol,endosome membrane,extrinsic component of membrane,clathrin-coated vesicle,retromer complex,early endosome membrane,early phagosome,extracellular exosome,
      • Expression:
      • Brain,Colon,Epithelium,Pancreas,Platelet,Skin,
      • Products Images
      • Western blot analysis of SNX3 Antibody. The lane on the right is blocked with the SNX3 peptide.
      • Western blot analysis of the lysates from HUVECcells using SNX3 antibody.