• Target：
• Relaxin Receptor 2

• Fields：
• >>Neuroactive ligand-receptor interaction;>>Relaxin signaling pathway

• Gene Name：
• RXFP2

• Protein Name：
• Relaxin receptor 2

• Human Gene Id：
• 122042

• Human Swiss Prot No：
• Q8WXD0

• Mouse Gene Id：
• 140498

• Mouse Swiss Prot No：
• Q91ZZ5

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human RXFP2. AA range:113-162

• Specificity：
• Relaxin Receptor 2 Polyclonal Antibody detects endogenous levels of Relaxin Receptor 2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RXFP2;GPR106;GREAT;LGR8;Relaxin receptor 2;G-protein coupled receptor 106;G-protein coupled receptor affecting testicular descent;Leucine-rich repeat-containing G-protein coupled receptor 8;Relaxin family peptide receptor 2

• Observed Band(KD)：
• 86kD

• Background：
• This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009],

• Function：
• caution:It is uncertain whether Met-1 or Met-18 is the initiator.,disease:Defects in RXFP2 are a cause of cryptorchidism [MIM:219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.,function:Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 10 LRR (leucine-rich) repeats.,tissue specificity:Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.

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