• Target：
• Recoverin

• Fields：
• >>Phototransduction

• Gene Name：
• RCVRN

• Protein Name：
• Recoverin

• Human Gene Id：
• 5957

• Human Swiss Prot No：
• P35243

• Mouse Gene Id：
• 19674

• Mouse Swiss Prot No：
• P34057

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Recoverin. AA range:107-156

• Specificity：
• Recoverin Polyclonal Antibody detects endogenous levels of Recoverin protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RCVRN;RCV1;Recoverin;Cancer-associated retinopathy protein;Protein CAR

• Observed Band(KD)：
• 23kD

• Background：
• This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008],

• Function：
• disease:Identified as the antigen in cancer-associated retinopathy, an autoimmune disease of the retina caused by a tumor in another tissue.,function:Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.,miscellaneous:Binds two calcium ions; one with high affinity, the other with low affinity.,similarity:Belongs to the recoverin family.,similarity:Contains 4 EF-hand domains.,tissue specificity:Retina and pineal gland.,

• Subcellular Location：
• Photoreceptor inner segment . Cell projection, cilium, photoreceptor outer segment . Photoreceptor outer segment membrane ; Lipid-anchor ; Cytoplasmic side . Perikaryon . Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity). Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity). .

• Expression：
• Retina and pineal gland.

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