• Target：
• Rabaptin-5α

• Fields：
• >>Endocytosis

• Gene Name：
• RABEP1

• Protein Name：
• Rab GTPase-binding effector protein 1

• Human Gene Id：
• 9135

• Human Swiss Prot No：
• Q15276

• Mouse Gene Id：
• 54189

• Mouse Swiss Prot No：
• O35551

• Rat Gene Id：
• 54190

• Rat Swiss Prot No：
• O35550

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human RABEP1. AA range:549-598

• Specificity：
• Rabaptin-5α Polyclonal Antibody detects endogenous levels of Rabaptin-5α protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RABEP1;RAB5EP;RABPT5;RABPT5A;Rab GTPase-binding effector protein 1;Rabaptin-4;Rabaptin-5;Rabaptin-5alpha;Renal carcinoma antigen NY-REN-17

• Molecular Weight(Da)：
• 99kD

• Background：
• function:Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A.,PTM:Proteolytic cleavage by caspases in apoptotic cells causes loss of endosome fusion activity.,similarity:Belongs to the rabaptin family.,subunit:Heterodimer with RABGEF1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2.,

• Function：
• function:Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A.,PTM:Proteolytic cleavage by caspases in apoptotic cells causes loss of endosome fusion activity.,similarity:Belongs to the rabaptin family.,subunit:Heterodimer with RABGEF1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2.,

• Subcellular Location：
• Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle.

• Expression：
• Cervix carcinoma,Epithelium,Fetal brain cortex,Kidney,Plate

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