• Target：
• PDK2

• Fields：
• >>Diabetic cardiomyopathy

• Gene Name：
• PDK2

• Protein Name：
• [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2 mitochondrial

• Human Gene Id：
• 5164

• Human Swiss Prot No：
• Q15119

• Mouse Gene Id：
• 18604

• Mouse Swiss Prot No：
• Q9JK42

• Rat Gene Id：
• 81530

• Rat Swiss Prot No：
• Q64536

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PDK2. AA range:260-309

• Specificity：
• PDK2 Polyclonal Antibody detects endogenous levels of PDK2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PDK2;PDHK2;[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2; mitochondrial;Pyruvate dehydrogenase kinase isoform 2

• Observed Band(KD)：
• 46kD

• Background：
• This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],

• Function：
• catalytic activity:ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.,function:Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.,similarity:Belongs to the PDK/BCKDK protein kinase family.,similarity:Contains 1 histidine kinase domain.,tissue specificity:Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.,

• Subcellular Location：
• Mitochondrion matrix.

• Expression：
• Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.

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