• Target：
• PAR-6β

• Fields：
• >>Rap1 signaling pathway;>>Endocytosis;>>Axon guidance;>>Hippo signaling pathway;>>Tight junction;>>Human papillomavirus infection

• Gene Name：
• PARD6B

• Protein Name：
• Partitioning defective 6 homolog beta

• Human Gene Id：
• 84612

• Human Swiss Prot No：
• Q9BYG5

• Mouse Gene Id：
• 58220

• Mouse Swiss Prot No：
• Q9JK83

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PARD6B. AA range:233-282

• Specificity：
• PAR-6β Polyclonal Antibody detects endogenous levels of PAR-6β protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PARD6B;PAR6B;Partitioning defective 6 homolog beta;PAR-6 beta;PAR-6B

• Observed Band(KD)：
• 38kD

• Background：
• This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008],

• Function：
• domain:The PDZ domain mediates interaction with MPP5.,domain:The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.,function:Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.,similarity:Belongs to the PAR6 family.,similarity:Contains 1 OPR domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 pseudo-CRIB domain.,subunit:Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and

• Subcellular Location：
• Cytoplasm. Cell membrane . Cell junction, tight junction .

• Expression：
• Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.

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