• Target：
• Nesprin-3

• Gene Name：
• SYNE3

• Protein Name：
• Nesprin-3

• Human Gene Id：
• 161176

• Human Swiss Prot No：
• Q6ZMZ3

• Mouse Gene Id：
• 212073

• Mouse Swiss Prot No：
• Q4FZC9

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human C14orf49. AA range:169-218

• Specificity：
• Nesprin-3 Polyclonal Antibody detects endogenous levels of Nesprin-3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SYNE3;C14orf49;Nesprin-3;Nuclear envelope spectrin repeat protein 3

• Observed Band(KD)：
• 115kD

• Background：
• function:Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which theters the nucleus to the cytoskeleton by binding PLEC1/Plectin which can associate with the intermediate filament system.,similarity:Belongs to the nesprin family.,similarity:Contains 1 KASH domain.,similarity:Contains 2 spectrin repeats.,subcellular location:Located at the rough reticulum endoplasmic (RER) in some cells.,subunit:Interacts with actin-binding domain of PLEC1/plectin.,

• Function：
• function:Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which theters the nucleus to the cytoskeleton by binding PLEC1/Plectin which can associate with the intermediate filament system.,similarity:Belongs to the nesprin family.,similarity:Contains 1 KASH domain.,similarity:Contains 2 spectrin repeats.,subcellular location:Located at the rough reticulum endoplasmic (RER) in some cells.,subunit:Interacts with actin-binding domain of PLEC1/plectin.,

• Subcellular Location：
• Nucleus outer membrane ; Single-pass type IV membrane protein . Nucleus envelope . Rough endoplasmic reticulum .

• Expression：
• Expressed in aortic endothelial cells (at protein level).

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