• Target：
• LZK

• Fields：
• >>MAPK signaling pathway

• Gene Name：
• MAP3K13

• Protein Name：
• Mitogen-activated protein kinase kinase kinase 13

• Human Gene Id：
• 9175

• Human Swiss Prot No：
• O43283

• Mouse Gene Id：
• 71751

• Mouse Swiss Prot No：
• Q1HKZ5

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human M3K13. AA range:151-200

• Specificity：
• LZK Polyclonal Antibody detects endogenous levels of LZK protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MAP3K13;LZK;Mitogen-activated protein kinase kinase kinase 13;Leucine zipper-bearing kinase;Mixed lineage kinase;MLK

• Observed Band(KD)：
• 108kD

• Background：
• The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by autophosphorylation and homodimerization.,function:Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.,PTM:Autophosphorylated on serine and threonine residues.,sequence caution:Translated as Tyr.,sequence caution:Wrong choice of CDS.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP

• Subcellular Location：
• Cytoplasm . Membrane ; Peripheral membrane protein .

• Expression：
• Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.

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