• Target：
• KPI-2

• Gene Name：
• LMTK2

• Protein Name：
• Serine/threonine-protein kinase LMTK2

• Human Gene Id：
• 22853

• Human Swiss Prot No：
• Q8IWU2

• Mouse Swiss Prot No：
• Q3TYD6

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human LMTK2. AA range:651-700

• Specificity：
• KPI-2 Polyclonal Antibody detects endogenous levels of KPI-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• LMTK2;AATYK2;BREK;KIAA1079;KPI2;LMR2;Serine/threonine-protein kinase LMTK2;Apoptosis-associated tyrosine kinase 2;Brain-enriched kinase;hBREK;CDK5/p35-regulated kinase;CPRK;Kinase/phosphatase/inhibitor 2;Lemur tyrosine kinase 2

• Observed Band(KD)：
• 164kD

• Background：
• The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009],

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates PPP1C, phosphorylase b and CFTR.,online information:LMTK2 entry,PTM:Autophosphorylated. Phosphorylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with PPP1C and inhibitor-2.,tissue specificity:Mainly expressed in skeletal muscle, and weakly in brain and pancreas.,

• Subcellular Location：
• Membrane ; Multi-pass membrane protein .

• Expression：
• Mainly expressed in skeletal muscle, and weakly in brain and pancreas.

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