• Target：
• GROα

• Fields：
• >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>NF-kappa B signaling pathway;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>TNF signaling pathway;>>Alcoholic liver disease;>>Epithelial cell signaling in Helicobacter pylori infection;>>Legionellosis;>>Amoebiasis;>>Kaposi sarcoma-associated herpesvirus infection;>>Rheumatoid arthritis;>>Lipid and atherosclerosis

• Gene Name：
• CXCL1

• Protein Name：
• Growth-regulated alpha protein

• Human Gene Id：
• 2919

• Human Swiss Prot No：
• P09341

• Mouse Gene Id：
• 14825

• Mouse Swiss Prot No：
• P12850

• Rat Gene Id：
• 81503

• Rat Swiss Prot No：
• P14095

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GROalpha. AA range:39-88

• Specificity：
• GROα Polyclonal Antibody detects endogenous levels of GROα protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CXCL1;GRO;GRO1;GROA;MGSA;SCYB1;Growth-regulated alpha protein;C-X-C motif chemokine 1;GRO-alpha(1-73);Melanoma growth stimulatory activity;MGSA;Neutrophil-activating protein 3;NAP-3

• Molecular Weight(Da)：
• 11kD

• Background：
• This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014],

• Function：
• function:Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.,online information:CXCL1 entry,PTM:N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,

• Subcellular Location：
• Secreted.

• Expression：
• Blood,Ovary,Peripheral blood monocyte,Placenta,Skin,

High expression level of CXCL1/GROα is linked to advanced stage and worse survival in uterine cervical cancer and facilitates tumor cell malignant processes IHC Human 1:100 uterine cervical tissue/

Crosstalk between cancer cells and macrophages promotes OSCC cell migration and invasion through a CXCL1/EGF positive feedback loop Discover Oncology Huang Wei IHC Human 1:100 oral squamous cell carcinoma (OSCC) tissue,epithelial tissue

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