• Target：
• GASP-1

• Gene Name：
• GPRASP1

• Protein Name：
• G-protein coupled receptor-associated sorting protein 1

• Human Gene Id：
• 9737

• Human Swiss Prot No：
• Q5JY77

• Mouse Swiss Prot No：
• Q5U4C1

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GASP1. AA range:741-790

• Specificity：
• GASP-1 Polyclonal Antibody detects endogenous levels of GASP-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GPRASP1;GASP;KIAA0443;G-protein coupled receptor-associated sorting protein 1;GASP-1

• Molecular Weight(Da)：
• 157kD

• Background：
• This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010],

• Function：
• function:May modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes.,similarity:Belongs to the GPRASP family.,subunit:Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine receptor/DRD2 (By similarity), delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4. Interacts with PER1.,tissue specificity:Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.,

• Subcellular Location：
• Cytoplasm .

• Expression：
• Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.

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