• Target：
• GAP-43

• Gene Name：
• GAP43

• Protein Name：
• Neuromodulin

• Human Gene Id：
• 2596

• Human Swiss Prot No：
• P17677

• Mouse Gene Id：
• 14432

• Mouse Swiss Prot No：
• P06837

• Rat Gene Id：
• 29423

• Rat Swiss Prot No：
• P07936

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GAP43. AA range:8-57

• Specificity：
• GAP-43 Polyclonal Antibody detects endogenous levels of GAP-43 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:20000. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GAP43;Neuromodulin;Axonal membrane protein GAP-43;Growth-associated protein 43;Neural phosphoprotein B-50;pp46

• Observed Band(KD)：
• 43kD

• Background：
• The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• Function：
• function:This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.,online information:Gap-43 entry,PTM:Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.,similarity:Belongs to the neuromodulin family.,similarity:Contains 1 IQ domain.,subcellular location:Cytoplasmic surface of growth cone and synaptic plasma membranes.,subunit:Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.,

• Subcellular Location：
• Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell projection, filopodium membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, axon . Cytoplasm . Cytoplasmic surface of growth cone and synaptic plasma membranes. .

• Expression：
• Alzheimer cortex,Brain,Subthalamic nucleus,

Mesenchymal stem cell-derived extracellular vesicles promote nerve regeneration after sciatic nerve crush injury in rats. International Journal of Clinical and Experimental Pathology Int J Clin Exp Patho. 2017; 10(9): 10032–10039 IHC Rat 1:200 Nerve tissue

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