GAP-43 Polyclonal Antibody

  • Catalog No.：YT1849
  • Applications：WB;IHC;IF;ELISA
  • Reactivity：Human;Mouse;Rat
    • Target：
    • GAP-43
    • Gene Name：
    • GAP43
    • Protein Name：
    • Neuromodulin
    • Human Gene Id：
    • 2596
    • Human Swiss Prot No：
    • P17677
    • Mouse Swiss Prot No：
    • P06837
    • Immunogen：
    • The antiserum was produced against synthesized peptide derived from human GAP43. AA range:8-57
    • Specificity：
    • GAP-43 Polyclonal Antibody detects endogenous levels of GAP-43 protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:20000. IF 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • GAP43;Neuromodulin;Axonal membrane protein GAP-43;Growth-associated protein 43;Neural phosphoprotein B-50;pp46
    • Observed Band(KD)：
    • 43kD
    • Background：
    • The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
    • Function：
    • function:This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.,online information:Gap-43 entry,PTM:Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.,similarity:Belongs to the neuromodulin family.,similarity:Contains 1 IQ domain.,subcellular location:Cytoplasmic surface of growth cone and synaptic plasma membranes.,subunit:Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.,
    • Subcellular Location：
    • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell projection, filopodium membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, axon . Cytoplasm . Cytoplasmic surface of growth cone and synaptic plasma membranes. .
    • Expression：
    • Alzheimer cortex,Brain,Subthalamic nucleus,

    Attributes

    • Code：
    • YT1849
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-11-24
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