FPR1 Polyclonal Antibody
- Catalog No.:YT1769
- Applications:WB;IF;ELISA
- Reactivity:Human;Rat;Mouse;
- Target:
- FPR1
- Fields:
- >>Rap1 signaling pathway;>>Neuroactive ligand-receptor interaction;>>Neutrophil extracellular trap formation;>>Staphylococcus aureus infection
- Gene Name:
- FPR1
- Protein Name:
- fMet-Leu-Phe receptor
- Human Gene Id:
- 2357
- Human Swiss Prot No:
- P21462
- Mouse Swiss Prot No:
- P33766
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human FPR1. AA range:151-200
- Specificity:
- FPR1 Polyclonal Antibody detects endogenous levels of FPR1 protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- FPR1;fMet-Leu-Phe receptor;fMLP receptor;N-formyl peptide receptor;FPR;N-formylpeptide chemoattractant receptor
- Observed Band(KD):
- 38kD
- Background:
- formyl peptide receptor 1(FPR1) Homo sapiens This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010],
- Function:
- function:High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.,PTM:Phosphorylated; which is necessary for desensitization.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Neutrophils.,
- Subcellular Location:
- Cell membrane ; Multi-pass membrane protein . Internalizes in presence of its ligands, fMLP, TAFA4 and CTSG. .
- Expression:
- Neutrophils.
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- Antibody-FAQs
- Products Images
- Immunofluorescence analysis of A549 cells, using FPR1 Antibody. The picture on the right is blocked with the synthesized peptide.
- Western blot analysis of lysates from DU145 cells, primary antibody was diluted at 1:1000, 4°over night