• Target：
• ENX-2

• Fields：
• >>Lysine degradation;>>Metabolic pathways

• Gene Name：
• EZH1

• Protein Name：
• Histone-lysine N-methyltransferase EZH1

• Human Gene Id：
• 2145

• Human Swiss Prot No：
• Q92800

• Mouse Gene Id：
• 14055

• Mouse Swiss Prot No：
• P70351

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human EZH1. AA range:171-220

• Specificity：
• ENX-2 Polyclonal Antibody detects endogenous levels of ENX-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• EZH1;KIAA0388;Histone-lysine N-methyltransferase EZH1;ENX-2;Enhancer of zeste homolog 1

• Observed Band(KD)：
• 85kD

• Background：
• enhancer of zeste 1 polycomb repressive complex 2 subunit(EZH1) Homo sapiens EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009],

• Function：
• catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,function:Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.,similarity:Belongs to the histone-lysine methyltransferase family. EZ subfamily.,similarity:Contains 1 SET domain.,s

• Subcellular Location：
• Nucleus . Colocalizes with trimethylated 'Lys-27' of histone H3.

• Expression：
• Brain,Hippocampus,Uterus,

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