• Target：
• EDG-5

• Fields：
• >>Sphingolipid signaling pathway;>>Neuroactive ligand-receptor interaction

• Gene Name：
• S1PR2

• Protein Name：
• Sphingosine 1-phosphate receptor 2

• Human Gene Id：
• 9294

• Human Swiss Prot No：
• O95136

• Mouse Gene Id：
• 14739

• Mouse Swiss Prot No：
• P52592

• Rat Gene Id：
• 29415

• Rat Swiss Prot No：
• P47752

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human EDG5. AA range:261-310

• Specificity：
• EDG-5 Polyclonal Antibody detects endogenous levels of EDG-5 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• S1PR2;EDG5;Sphingosine 1-phosphate receptor 2;S1P receptor 2;S1P2;Endothelial differentiation G-protein coupled receptor 5;Sphingosine 1-phosphate receptor Edg-5;S1P receptor Edg-5

• Observed Band(KD)：
• 39kD

• Background：
• This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016],

• Function：
• function:Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.,similarity:Belongs to the G-protein coupled receptor 1 family.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Fetal brain,

Salidroside Inhibits CCl4-Induced Liver Fibrosis in Mice by Reducing Activation and Migration of HSC Induced by Liver Sinusoidal Endothelial Cell-Derived Exosomal SphK1. Frontiers in Pharmacology Front Pharmacol. 2021 May;0:1195 WB Mouse，Human Liver，serum exosomes

Integration of metabolomics and transcriptomics analyses reveals sphingosine-1-phosphate-mediated S1PR2/PI3K/Akt pathway involved in Talaromyces marneffei infection of macrophages MICROBIAL PATHOGENESIS Yi-Qun Kuang WB,IHC Mouse lung J774A.1 macrophages

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