• Target：
• CTPS

• Fields：
• >>Pyrimidine metabolism;>>Metabolic pathways;>>Nucleotide metabolism;>>Biosynthesis of cofactors

• Gene Name：
• CTPS1

• Protein Name：
• CTP synthase 1

• Human Gene Id：
• 1503

• Human Swiss Prot No：
• P17812

• Mouse Gene Id：
• 51797

• Mouse Swiss Prot No：
• P70698

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CTPS. AA range:60-109

• Specificity：
• CTPS Polyclonal Antibody detects endogenous levels of CTPS protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CTPS1;CTPS;CTP synthase 1;CTP synthetase 1;UTP--ammonia ligase 1

• Observed Band(KD)：
• 67kD

• Background：
• This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

• Function：
• catalytic activity:ATP + UTP + NH(3) = ADP + phosphate + CTP.,enzyme regulation:Activated by GTP and inhibited by CTP.,function:Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.,pathway:Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.,similarity:Belongs to the CTP synthase family.,similarity:Contains 1 glutamine amidotransferase type-1 domain.,

• Subcellular Location：
• Cytoplasm, cytosol . Mainly cytosolic but when active detected in long filamentous structures (PubMed:25223282). Co-localizes with TNK2 in the cytosolic filaments (By similarity). .

• Expression：
• Widely expressed.

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