• Target：
• CLIC6

• Gene Name：
• CLIC6

• Protein Name：
• Chloride intracellular channel protein 6

• Human Gene Id：
• 54102

• Human Swiss Prot No：
• Q96NY7

• Mouse Swiss Prot No：
• Q8BHB9

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CLIC6. AA range:411-460

• Specificity：
• CLIC6 Polyclonal Antibody detects endogenous levels of CLIC6 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CLIC6;CLIC1L;Chloride intracellular channel protein 6;Parchorin

• Observed Band(KD)：
• 75kD

• Background：
• chloride intracellular channel 6(CLIC6) Homo sapiens This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015],

• Function：
• domain:Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.,function:May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport.,PTM:Phosphorylated.,similarity:Belongs to the chloride channel CLIC family.,similarity:Contains 1 GST C-terminal domain.,subcellular location:Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane.,subunit:Interacts with dopamine receptors DRD2, DRD3 and DRD4.,tissue specificity:Expressed in brain, placenta, pancreas and liver.,

• Subcellular Location：
• Cytoplasm . Cell membrane ; Single-pass membrane protein . Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). .

• Expression：
• Expressed in brain, placenta, pancreas and liver.

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