CLIC6 Polyclonal Antibody
- Catalog No.:YT0966
- Applications:WB;ELISA
- Reactivity:Human;Rat;Mouse;
- Target:
- CLIC6
- Gene Name:
- CLIC6
- Protein Name:
- Chloride intracellular channel protein 6
- Human Gene Id:
- 54102
- Human Swiss Prot No:
- Q96NY7
- Mouse Swiss Prot No:
- Q8BHB9
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CLIC6. AA range:411-460
- Specificity:
- CLIC6 Polyclonal Antibody detects endogenous levels of CLIC6 protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- CLIC6;CLIC1L;Chloride intracellular channel protein 6;Parchorin
- Observed Band(KD):
- 75kD
- Background:
- chloride intracellular channel 6(CLIC6) Homo sapiens This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015],
- Function:
- domain:Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.,function:May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport.,PTM:Phosphorylated.,similarity:Belongs to the chloride channel CLIC family.,similarity:Contains 1 GST C-terminal domain.,subcellular location:Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane.,subunit:Interacts with dopamine receptors DRD2, DRD3 and DRD4.,tissue specificity:Expressed in brain, placenta, pancreas and liver.,
- Subcellular Location:
- Cytoplasm . Cell membrane ; Single-pass membrane protein . Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). .
- Expression:
- Expressed in brain, placenta, pancreas and liver.
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- Antibody-FAQs
- Products Images
- Western blot analysis of CLIC6 Antibody. The lane on the right is blocked with the CLIC6 peptide.
- Western blot analysis of the lysates from HepG2 cells using CLIC6 antibody.