• Target：
• Cdc23

• Fields：
• >>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>Progesterone-mediated oocyte maturation;>>Human T-cell leukemia virus 1 infection

• Gene Name：
• CDC23

• Protein Name：
• Cell division cycle protein 23 homolog

• Human Gene Id：
• 8697

• Human Swiss Prot No：
• Q9UJX2

• Mouse Gene Id：
• 52563

• Mouse Swiss Prot No：
• Q8BGZ4

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human APC8. AA range:251-300

• Specificity：
• Cdc23 Polyclonal Antibody detects endogenous levels of Cdc23 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CDC23;ANAPC8;Cell division cycle protein 23 homolog;Anaphase-promoting complex subunit 8;APC8;Cyclosome subunit 8

• Observed Band(KD)：
• 69kD

• Background：
• The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008],

• Function：
• function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Thr-556 occurs specifically during mitosis.,similarity:Belongs to the APC8/CDC23 family.,similarity:Contains 9 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits.,

• Subcellular Location：
• intracellular,nucleoplasm,anaphase-promoting complex,cytosol,

• Expression：
• Bone marrow,Brain,Duodenum,Epithelium,Pancreas,Placenta,

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