• Target：
• Calpain 11

• Gene Name：
• CAPN11

• Protein Name：
• Calpain-11

• Human Gene Id：
• 11131

• Human Swiss Prot No：
• Q9UMQ6

• Mouse Swiss Prot No：
• Q6J756

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CAPN11. AA range:401-450

• Specificity：
• Calpain 11 Polyclonal Antibody detects endogenous levels of Calpain 11 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CAPN11;Calpain-11;Calcium-activated neutral proteinase 11;CANP 11

• Observed Band(KD)：
• 81kD

• Background：
• Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008],

• Function：
• catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 2 EF-hand domains.,subunit:Heterodimer of a large (catalytic) and a small (regulatory) subunit.,tissue specificity:Highest expression in testis.,

• Subcellular Location：
• Cytoplasmic vesicle, secretory vesicle, acrosome .

• Expression：
• Highest expression in testis.

3, 3'-Diindolylmethane induces gastric cancer cells death via STIM1 mediated store-operated calcium entry." International Journal of Biological Sciences 17.5 (2021): 1217.

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