• Target：
• Calgizzarin

• Gene Name：
• S100A11

• Protein Name：
• Protein S100-A11

• Human Gene Id：
• 6282

• Human Swiss Prot No：
• P31949

• Mouse Gene Id：
• 20195

• Mouse Swiss Prot No：
• P50543

• Rat Gene Id：
• 445415

• Rat Swiss Prot No：
• Q6B345

• Immunogen：
• Synthesized peptide derived from Calgizzarin . at AA range: 30-110

• Specificity：
• Calgizzarin Polyclonal Antibody detects endogenous levels of Calgizzarin protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• S100A11;MLN70;S100C;Protein S100-A11;Calgizzarin;Metastatic lymph node gene 70 protein;MLN 70;Protein S100-C;S100 calcium-binding protein A11

• Molecular Weight(Da)：
• 12kD

• Background：
• The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008],

• Function：
• function:Facilitates the differentiation and the cornification of keratinocytes.,miscellaneous:Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins.,PTM:Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Homodimer; disulfide-linked.,

• Subcellular Location：
• Cytoplasm . Nucleus .

• Expression：
• Brain,Epithelium,Keratinocyte,Lung,Mammary carcinoma,Placenta,Urina

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