BCSC-1 Polyclonal Antibody

    • Catalog No.：YT0483
    • Applications：WB;ELISA
    • Reactivity：Human;Rat;Mouse;
      • Target：
      • BCSC-1
      • Gene Name：
      • VWA5A
      • Protein Name：
      • von Willebrand factor A domain-containing protein 5A
      • Human Gene Id：
      • 4013
      • Human Swiss Prot No：
      • O00534
      • Mouse Swiss Prot No：
      • Q99KC8
      • Immunogen：
      • The antiserum was produced against synthesized peptide derived from human LHR2A. AA range:371-420
      • Specificity：
      • BCSC-1 Polyclonal Antibody detects endogenous levels of BCSC-1 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • VWA5A;BCSC1;LOH11CR2A;von Willebrand factor A domain-containing protein 5A;Breast cancer suppressor candidate 1;BCSC-1;Loss of heterozygosity 11 chromosomal region 2 gene A protein
      • Observed Band(KD)：
      • 86kD
      • Background：
      • VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A. Existing as four alternatively spliced isoforms, the gene encoding VWA5A maps to human chromosome 11q24.2.
      • Subcellular Location：
      • nucleus,nucleoplasm,
      • Expression：
      • Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested.
      • Products Images
      • Western Blot analysis of various cells using BCSC-1 Polyclonal Antibody
      • Western blot analysis of lysates from 293 cells, using LHR2A Antibody. The lane on the right is blocked with the synthesized peptide.

      Attributes

      • Code：
      • YT0483
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-07-19
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