ApoER2 Polyclonal Antibody

    • Catalog No.：YT0275
    • Applications：WB;ELISA
    • Reactivity：Human;Rat;Mouse;
      • Target：
      • ApoER2
      • Gene Name：
      • LRP8
      • Protein Name：
      • Low-density lipoprotein receptor-related protein 8
      • Human Swiss Prot No：
      • Q14114
      • Mouse Swiss Prot No：
      • Q924X6
      • Immunogen：
      • The antiserum was produced against synthesized peptide derived from human LRP8. AA range:451-500
      • Specificity：
      • ApoER2 Polyclonal Antibody detects endogenous levels of ApoER2 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • LRP8;APOER2;Low-density lipoprotein receptor-related protein 8;LRP-8;Apolipoprotein E receptor 2
      • Observed Band(KD)：
      • 100kD
      • Background：
      • This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011],
      • Function：
      • alternative products:Additional isoforms seem to exist. No differences were observed in the pattern splicing between control and Alzheimer brains,disease:Genetic variation in LRP8 is associated with susceptibility to myocardial infarction type 1 [MIM:608446]. Atherosclerotic coronary artery disease (CAD) and myocardial infarction (MI) are complex traits that account for the leading cause of death in the Western world heart disease.,domain:The cytoplasmic domain is involved in the binding of DAB1 and in the recruitment of JNK-interacting proteins. Isoforms, which lack part of the cytoplasmic domain, are unable to recruit members of the family of JNK interacting proteins (JIP) to the cytoplasmic tail.,function:Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling p
      • Subcellular Location：
      • Cell membrane ; Single-pass type I membrane protein . Secreted . Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment. .
      • Expression：
      • Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver.
      • Products Images
      • Western blot analysis of the lysates from HeLa cells using LRP8 antibody.

      Attributes

      • Code：
      • YT0275
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-07-20
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