• Target：
• p120 Catenin

• Fields：
• >>Rap1 signaling pathway;>>Adherens junction;>>Leukocyte transendothelial migration

• Gene Name：
• CTNND1 KIAA0384

• Protein Name：
• Cadherin associated Src substrate;Cadherin-associated Src substrate;CAS;Catenin (cadherin associated protein) delta 1;Catenin delta 1;Catenin delta;Catenin delta-1;CTND1_HUMAN;CTNND 1;CTNND;CTNND1;del

• Human Swiss Prot No：
• O60716

• Mouse Swiss Prot No：
• P30999

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Cadherin associated Src substrate;Cadherin-associated Src substrate;CAS;Catenin (cadherin associated protein) delta 1;Catenin delta 1;Catenin delta;Catenin delta-1;CTND1_HUMAN;CTNND 1;CTNND;CTNND1;delta 1 Catenin;KIAA0384;p120;P120 CAS;p120 catenin;P120 CTN;p120(cas);p120(ctn);P120CAS;P120CTN

• Molecular Weight(Da)：
• 108kD

• Observed Band(KD)：
• 108kD

• Background：
• catenin delta 1(CTNND1) Homo sapiens This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010],

• Function：
• alternative products:Experimental confirmation may be lacking for some isoforms,disease:May contribute to cell malignancy. Complete loss of expression was observed in approximately 10% of invasive ductal breast carcinomas investigated.,domain:A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.,function:Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.,induction:Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound clo

• Subcellular Location：
• Membrane

• Expression：
• Breast/ Tonsil

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