Cytokeratin 20 (CK20) (ABT24R) rabbit mAb
- Catalog No.：YM7261
- Applications：IHC; ELISA
- Reactivity：Human; Mouse (predicted: Rat)
- Target：
- Cytokeratin 20
- Fields：
- >>Estrogen signaling pathway;>>Staphylococcus aureus infection
- Gene Name：
- KRT20
- Protein Name：
- Cytokeratin-20
- Human Gene Id：
- 54474
- Human Swiss Prot No：
- P35900
- Immunogen：
- Synthesized peptide derived from human CK20 AA range:300-424
- Specificity：
- This antibody detects endogenous levels of Cytokeratin 20
- Formulation：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- Source：
- Monoclonal, Rabbit IgG1, Kappa
- Dilution：
- IHC 1:100-500, ELISA 1:5000-20000
- Purification：
- Recombinant Expression and Affinity purified
- Storage Stability：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name：
- CD20;CK 20;CK-20;CK20;CytokeRatin-20;CytokeRatin20;K1C20_HUMAN;K20;KA20;KeRatin 20;keRatin 20, type I;keRatin 21, Rat, homolog of;KeRatin;KeRatin type I cytoskeletal 20;KeRatin-20;KeRatin20;KRT 20;KRT 21;KRT20;KRT21;MGC35423;OTTHUMP00000164518;Protein IT;type I cytoskeletal 20
- Background：
- The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008],
- Function：
- developmental stage:First detected at embryonic week 8 in individual 'converted' simple epithelial cells of the developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number of villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells as well as certain 'low-differentiated' columnar cells, whereas the neuroendocrine and Paneth cells are negative.,function:Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during t
- Subcellular Location：
- Cytoplasmic, Membranous
- Expression：
- Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.
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- Antibody-FAQs
- Products Images
- Immunohistochemical analysis of paraffin-embedded human Bladder. 1, Antibody was incubated at 4° overnight. 2, TRIS-EDTA of pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
- Immunohistochemical analysis of paraffin-embedded human Colon carcinoma. 1, Antibody was incubated at 4° overnight. 2, TRIS-EDTA of pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
