• Target：
• Calumenin

• Gene Name：
• calu

• Human Gene Id：
• 813

• Human Swiss Prot No：
• O43852

• Mouse Swiss Prot No：
• O35887

• Immunogen：
• Purified recombinant human Calumenin protein fragments expressed in E.coli.

• Specificity：
• This antibody detects endogenous levels of Calumenin and does not cross-react with related proteins.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• wb 1:1000

• Purification：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CALU;CALU_HUMAN;Calumenin 1;Calumenin 2;Calumenin;Crocalbin;crocalbin-like protein;FLJ90608;IEF SSP 9302;multiple EF-hand protein;OTTHUMP00000212712;OTTHUMP00000212713;OTTHUMP00000212714;OTTHUMP00000212715.

• Observed Band(KD)：
• 37kD

• Background：
• calumenin(CALU) Homo sapiens The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008],

• Function：
• function:Involved in regulation of vitamin K-dependent carboxylation of multiple amino-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity.,similarity:Belongs to the CREC family.,similarity:Contains 6 EF-hand domains.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with GGCX.,tissue specificity:Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.,

• Subcellular Location：
• Endoplasmic reticulum membrane . Golgi apparatus . Secreted . Melanosome . Sarcoplasmic reticulum lumen . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .

• Expression：
• Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.

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